Document Detail


Exercise increases utrophin protein expression in the mdx mouse model of Duchenne muscular dystrophy.
MedLine Citation:
PMID:  24375286     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Duchenne muscular dystrophy (DMD) is a lethal genetic disease caused by mutations in the dystrophin gene resulting in chronic muscle damage, muscle wasting, and premature death. Utrophin is a dystrophin protein homologue that increases dystrophic muscle function and reduces pathology. Currently, no treatments that increase utrophin protein expression exist. However, exercise increases utrophin mRNA expression in healthy humans. Therefore, the purpose was to determine whether exercise increases utrophin protein expression in dystrophic muscle.
METHODS: Utrophin protein was measured in the quadriceps and soleus muscles of mdx mice after 12 weeks of voluntary wheel running exercise or sedentary controls. Muscle pathology was measured in the quadriceps.
RESULTS: Exercise increased utrophin protein expression 334 ± 63% in the quadriceps relative to sedentary controls. Exercise increased central nuclei 4 ± 1% but not other measures of pathology.
CONCLUSIONS: Exercise may be an intervention that increases utrophin expression in patients with DMD.
Authors:
Bradley S Gordon; Dawn A Lowe; Matthew C Kostek
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Muscle & nerve     Volume:  49     ISSN:  1097-4598     ISO Abbreviation:  Muscle Nerve     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-05-19     Completed Date:  2014-07-08     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  915-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal
Female
Gene Expression
Male
Mice
Mice, Inbred mdx
Muscle, Skeletal / metabolism*,  pathology,  physiopathology
Muscular Dystrophy, Duchenne / metabolism*,  pathology,  physiopathology
Physical Conditioning, Animal / physiology*
RNA, Messenger / metabolism
Utrophin / metabolism*
Grant Support
ID/Acronym/Agency:
K02-AG036827/AG/NIA NIH HHS; P30-AR0507220/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/RNA, Messenger; 0/Utrophin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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