| Exercise effects on motor and affective behavior and catecholamine neurochemistry in the MPTP-lesioned mouse. | |
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MedLine Citation:
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PMID: 20472000 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study used 1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine (MPTP) in mice to determine if exercise improves behavior and dopamine (DA) and serotonin (5HT) content. Male C57BL/6 mice received MPTP (4 x 20mg/kg) or saline. They remained sedentary or exercised by treadmill or voluntary running wheel for 6 weeks (n=8/group). Saline-treated mice ran significantly faster on running wheels (22.8+/-1.0m/min) than on treadmill (8.5+/-0.5m/min), and MPTP lesion did not reduce voluntary exercise (19.3+/-1.5m/min, p>0.05). There was a significant effect of both lesion and exercise on overall Rotarod performance (ORP): MPTP lesion reduced ORP, while treadmill exercise increased ORP vs sedentary mice (p<0.05). MPTP increased anxiety in the marble-burying test: sedentary lesioned mice buried more marbles (74.0+/-5.2%) than sedentary controls (34.8+/-11.8%, p<0.05). Conversely, exercise reduced anxiety on the elevated plus maze. Among saline-treated mice, those exposed to voluntary wheel-running showed an increased percent of open arm entries (49.8+/-3.5%, p<0.05) relative to sedentary controls (36.2+/-4.0%, p<0.05). Neither MPTP nor exercise altered symptoms of depression measured by sucrose preference or tail suspension. MPTP significantly reduced DA in striatum (in sedentary lesioned mice to 42.1+/-3.0% of saline controls), and lowered 5HT in amygdala and striatum (in sedentary lesioned mice to 86.1+/-4.1% and 66.5+/-8.2% of saline controls, respectively); exercise had no effect. Thus, exercise improves behavior in a model of DA depletion, without changes in DA or 5HT. |
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Authors:
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Lori M Gorton; Marta G Vuckovic; Nina Vertelkina; Giselle M Petzinger; Michael W Jakowec; Ruth I Wood |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-05-21 |
Journal Detail:
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Title: Behavioural brain research Volume: 213 ISSN: 1872-7549 ISO Abbreviation: Behav. Brain Res. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-10-19 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 8004872 Medline TA: Behav Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 253-62 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Cell and Neurobiology, Keck School of Medicine of the University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Animals Anxiety / metabolism, physiopathology Behavior, Animal / drug effects, physiology* Brain / drug effects, metabolism*, physiopathology* Corticosterone / blood Depression / metabolism, physiopathology Disease Models, Animal Dopamine / metabolism* Male Mice Mice, Inbred C57BL Motor Activity / drug effects, physiology* Parkinson Disease / metabolism, physiopathology* Physical Conditioning, Animal / physiology*, psychology* Rotarod Performance Test Serotonin / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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DC009125/DC/NIDCD NIH HHS; K18 DC009125-01/DC/NIDCD NIH HHS; NS44327/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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28289-54-5/1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 50-22-6/Corticosterone; 50-67-9/Serotonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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