Document Detail


Exercise effects on depressive symptoms in cancer survivors: a systematic review and meta-analysis.
MedLine Citation:
PMID:  22068286     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Depression is a distressing side effect of cancer and its treatment. In the general population, exercise is an effective antidepressant.
OBJECTIVE: We conducted a systematic review and meta-analysis to determine the antidepressant effect of exercise in cancer survivors.
DATA SOURCES: In May 2011, we searched MEDLINE, PsycInfo, EMBASE, CINAHL, CDSR, CENTRAL, AMED, Biosis Previews, and Sport Discus and citations from relevant articles and reviews.
STUDY ELIGIBILITY CRITERIA: We included randomized controlled trials (RCT) comparing exercise interventions with usual care in cancer survivors, using a self-report inventory or clinician rating to assess depressive symptoms, and reporting symptoms pre- and postintervention.
STUDY APPRAISAL: Around 7,042 study titles were identified and screened, with 15 RCTs included.
SYNTHESIS METHODS: Effect sizes (ES) were reported as mean change scores. The Q test was conducted to evaluate heterogeneity of ES. Potential moderator variables were evaluated with examination of scatter plots and Wilcoxon rank-sum or Kruskal-Wallis tests.
RESULTS: The overall ES, under a random-effects model, was -0.22 (confidence interval, -0.43 to -0.09; P = 0.04). Significant moderating variables (ps < 0.05) were exercise location, exercise supervision, and exercise duration.
LIMITATIONS: Only one study identified depression as the primary endpoint.
CONCLUSIONS: Exercise has modest positive effects on depressive symptoms with larger effects for programs that were supervised or partially supervised, not conducted at home, and at least 30 minutes in duration.
IMPACT: Our results complement other studies showing that exercise is associated with reduced pain and fatigue and with improvements in quality of life among cancer survivors.
Authors:
Lynette L Craft; Erik H Vaniterson; Irene B Helenowski; Alfred W Rademaker; Kerry S Courneya
Related Documents :
21594696 - Venous gas embolism as a predictive tool for improving cns decompression safety.
19759996 - Home-based exercise to alleviate fatigue and improve functional capacity among breast c...
22455626 - Impact of aerobic exercise trials with varied intensity patterns on perceptions of effo...
16257486 - Chemosensory anxiety signals augment the startle reflex in humans.
11993266 - Application and evaluation of a combination of socratice and learning through discussio...
18601666 - New zealand optometrists 2006: demographics, working arrangements and hours worked.
Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-11-08
Journal Detail:
Title:  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology     Volume:  21     ISSN:  1538-7755     ISO Abbreviation:  Cancer Epidemiol. Biomarkers Prev.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-09     Completed Date:  2012-04-25     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  9200608     Medline TA:  Cancer Epidemiol Biomarkers Prev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3-19     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Depression / psychology,  therapy*
Exercise / psychology*
Humans
Neoplasms / psychology*
Physical Fitness
Quality of Life
Survivors
Grant Support
ID/Acronym/Agency:
1K07CA134936-01A1/CA/NCI NIH HHS; K07 CA134936/CA/NCI NIH HHS; K07 CA134936-01A1/CA/NCI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Use of nonsteroidal anti-inflammatory drugs and survival following breast cancer diagnosis.
Next Document:  Long-term cancer risk among people diagnosed with AIDS during childhood.