Document Detail

Exercise dose response in muscle.
MedLine Citation:
PMID:  22261824     Owner:  NLM     Status:  MEDLINE    
Exercise increases peak VO2 partially through muscle adaptations. However, understanding muscle adaptations related to exercise dose is incomplete. This study investigated exercise training dose on capillaries per fiber and capillaries per area; and citrate synthase from vastus lateralis and related both to changes in peak VO2. This randomized trial compared 3 exercise doses: low amount-moderate intensity (n=40), low amount-high intensity (n=47), high amount-high intensity (n=41), and a control group (n=35). Both measures of capillary supply increased in all exercise groups (p<0.05). Low amount-high intensity and high amount-high intensity improved citrate synthase (p<0.05) and the low amount-moderate intensity citrate synthase approached significance (p=0.059). Muscle improvements were only related to improvements in peak VO2 in high amount-high intensity (citrate synthase, r=0.304; capillaries:fiber, r= - 0.318; p<0.05 and capillaries/mm2 r= - 0.310, p<0.05). These data suggest muscle adaptations occur following both low and high exercise doses, but are only related to improved peak VO2 following high amount-high intensity training.
B D Duscha; B H Annex; J L Johnson; K Huffman; J Houmard; W E Kraus
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2012-01-19
Journal Detail:
Title:  International journal of sports medicine     Volume:  33     ISSN:  1439-3964     ISO Abbreviation:  Int J Sports Med     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-01     Completed Date:  2012-06-15     Revised Date:  2013-09-17    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  218-23     Citation Subset:  IM    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Division of Rheumatology, Medical Center, Duke University, Durham, NC, USA.
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MeSH Terms
Citrate (si)-Synthase / metabolism*
Exercise / physiology*
Exercise Test
Middle Aged
Muscle, Skeletal / metabolism*
Oxygen Consumption / physiology*
Grant Support
Reg. No./Substance:
EC (si)-Synthase

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