| Exercise Does Not Attenuate Early Coronary Artery Disease Progression in a Pig Model. | |
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MedLine Citation:
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PMID: 21685817 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE:: This study was designed to examine the effects of high fat (HF) diet and subsequent exercise training (Ex) on coronary arteries of an animal model of early stage coronary artery disease (CAD). We hypothesized that HF diet would induce early stage disease and promote a pro-atherogenic coronary phenotype, while Ex would blunt disease progression and induce a healthier anti-inflammatory environment reflected by increased expression of antioxidant capacity and decreased expression of inflammatory markers in both the macro and microvasculature of the coronary circulation. METHODS:: Immunohistochemistry in left anterior descending (LAD) and right coronary arteries (RCA), and immunoblots in LAD and left ventricular (LV) arterioles were used to characterize effects of HF diet and Ex on the progression of coronary atherosclerosis. RESULTS:: Our results revealed that HF diet promoted a pro-atherogenic coronary endothelial cell phenotype as evidenced by the endothelial expression of inflammatory and oxidative stress markers. Ex did not significantly alter any of these immunohistochemical markers in conduit arteries; however, Ex did increase antioxidant protein content in LV arterioles. CONCLUSIONS:: We conclude that, at this early stage of CAD, Ex did not seem to modify vascular cell phenotypes of conduit coronary arteries from pro- to a more favorable anti-atherogenic status; however, Ex increased antioxidant protein content in coronary arterioles. These findings also support the idea that endothelial phenotype expression follows different patterns in the macro and microvasculature of the coronary circulation. |
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Authors:
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Arturo A Arce-Esquivel; Kurt V Kreutzer; James W E Rush; James R Turk; M Harold Laughlin |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-16 |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: - ISSN: 1530-0315 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Departments of 1Biomedical Sciences, and 2Medical Pharmacology and Physiology, 3Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO. 4Department of Kinesiology, University of Waterloo, Waterloo Ontario, Canada N2L 3G1. 5Amgen Inc., Thousand Oaks, CA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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