Document Detail

Exercise does not attenuate early CAD progression in a pig model.
MedLine Citation:
PMID:  21685817     Owner:  NLM     Status:  MEDLINE    
PURPOSE: This study was designed to examine the effects of high-fat (HF) diet and subsequent exercise training (Ex) on coronary arteries of an animal model of early stage CAD. We hypothesized that HF diet would induce early stage disease and promote a proatherogenic coronary phenotype, whereas Ex would blunt disease progression and induce a healthier anti-inflammatory environment reflected by the increased expression of antioxidant capacity and the decreased expression of inflammatory markers in both the macrovasculature and the microvasculature of the coronary circulation.
METHODS: Immunohistochemistry in left anterior descending and right coronary arteries and immunoblots in left anterior descending and left ventricular arterioles were used to characterize the effects of HF diet and Ex on the progression of coronary atherosclerosis.
RESULTS: Our results revealed that HF diet promoted a proatherogenic coronary endothelial cell phenotype as evidenced by the endothelial expression of inflammatory and oxidative stress markers. Ex did not significantly alter any of these immunohistochemical markers in conduit arteries; however, Ex did increase antioxidant protein content in left ventricular arterioles.
CONCLUSIONS: We conclude that, at this early stage of CAD, Ex did not seem to modify vascular cell phenotypes of conduit coronary arteries from proatherogenic to a more favorable antiatherogenic status; however, Ex increased antioxidant protein content in coronary arterioles. These findings also support the idea that endothelial phenotype expression follows different patterns in the macrovasculature and microvasculature of the coronary circulation.
Arturo A Arce-Esquivel; Kurt V Kreutzer; James W E Rush; James R Turk; M Harold Laughlin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  44     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-19     Completed Date:  2012-04-25     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  27-38     Citation Subset:  IM; S    
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MeSH Terms
Arterioles / pathology,  physiopathology
Biological Markers / analysis
Coronary Artery Disease / pathology,  physiopathology,  therapy*
Diet, High-Fat*
Disease Models, Animal
Disease Progression*
Endothelium, Vascular / pathology,  physiopathology
Hypercholesterolemia / physiopathology
Inflammation / pathology
Microvessels / pathology,  physiopathology
Oxidative Stress / physiology
Physical Conditioning, Animal / physiology*
Grant Support
Reg. No./Substance:
0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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