| Exercise Capacity in Patients With Severe Symptomatic Aortic Stenosis Before and Six Months After Transcatheter Aortic Valve Implantation. | |
| | |
MedLine Citation:
|
PMID: 21545988 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Few data exist on the use of the 6-minute walk test (6MWT) to measure the exercise capacity of patients with severe symptomatic aortic stenosis considered at very high surgical risk. The objectives of the present prospective study were (1) to determine the feasibility and safety of the 6MWT as a measure of exercise capacity before and after transcatheter aortic valve implantation (TAVI), and (2) to determine the clinical and hemodynamic parameters associated with the exercise capacity changes in such patients. A total of 64 patients (age 80 ± 8 years, logistic European System for Cardiac Operative Risk Evaluation score 21 ± 15%, Society of Thoracic Surgeons' score 7.5 ± 3.9%) who had undergone successful TAVI were included. The 6MWT was performed within the month before TAVI and at the 6-month follow-up visit. The mean distance walked increased from 165.3 ± 79.7 to 231.7 ± 88.9 m (p <0.0001); however, up to 25% of the patients did not improve or even decreased their exercise capacity. After adjustment for the baseline distance walked, multilinear regression analysis showed that a greater degree of renal dysfunction, as evaluated by the serum creatinine levels (r(2) = 0.05, p = 0.03), lower postprocedural hemoglobin values (r(2) = 0.13, p = 0.0012), and a longer hospitalization length (r(2) = 0.08, p = 0.007) were associated with lower improvement in exercise capacity. In conclusion, exercise capacity, as evaluated by the 6MWT, was very poor in patients with severe symptomatic aortic stenosis considered at very high surgical risk. TAVI was associated with a significant increase in exercise capacity, although no improvement was observed in 1/4 of the patients. A greater degree in renal dysfunction, lower postprocedural hemoglobin values, and longer hospitalization stay were predictors of lower improvement in exercise capacity after TAVI. These results suggest that the 6MWT might become an important tool as a part of the evaluation process for TAVI candidates. |
| | |
Authors:
|
Rodrigo Bagur; Josep Rodés-Cabau; Eric Dumont; Robert De Larochellière; Daniel Doyle; Olivier F Bertrand; Mélanie Côté; Paul Poirier; Philippe Pibarot |
Related Documents
:
|
22462368 - Orthostatic hypotension after 10 days of exercise-heat acclimation and 28 hours of slee... 7038838 - Exercise-induced proteinuria in children and adolescents. 1888358 - Physiotherapy for stress urinary incontinence: a national survey. 18568748 - Role of loose feathers on the development of feather pecking in laying hens. 11688678 - The response of shoot accumulation of trace elements in chinese cabbage to microclimate... 8501408 - Postexercise changes of the qtc interval in patients with recent myocardial infarction. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-5-3 |
Journal Detail:
|
Title: The American journal of cardiology Volume: - ISSN: 1879-1913 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-5-6 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: "Repaired" Tetralogy of Fallot Mimicking Arrhythmogenic Right Ventricular Cardiomyopathy (Another Ph...
Next Document: Long-Term Pulmonary Hemodynamic Effects of Ambrisentan in Pulmonary Arterial Hypertension.