Document Detail

Exercise and bipolar disorder: a review of neurobiological mediators.
MedLine Citation:
PMID:  19649751     Owner:  NLM     Status:  MEDLINE    
Extant evidence indicates that individuals with bipolar disorder (BD) are differentially affected by overweight/obesity and abdominal obesity. Excess weight is associated with a more complex illness presentation, non-recovery, and recurrence. Herein, we sought to review literature describing the effects of structured individualized physical exercise on disparate neurobiological substrates implicated in the pathophysiology of BD. We conducted a PubMed search of all English-language articles published between 1966 and July 2008 with BD cross-referenced with the following search terms: exercise, neurobiology, pathophysiology, pathoetiology, brain, cognition, neuroplasticity, and neurodegeneration. Articles selected for review were based on adequacy of sample size, the use of standardized experimental procedures, validated assessment measures, and overall manuscript quality. Contemporary models of disease pathophysiology in BD implicate disturbances in cellular resilience, plasticity, and survival in the central nervous system. Individualized exercise interventions are capable of alleviating the severity of affective and cognitive difficulties in heterogeneous samples. It is posited that exercise is a pleiotropic intervention that engages aberrant neurobiological systems implicated in metabolism, immuno-inflammatory function, and cellular respiration. Structured exercise regimens exert a salutary effect on interacting networks mediating metabolism, immuno-inflammatory function, and cellular respiration. In keeping this view, buttressed by controlled evidence describing robust anti-depressant effects with exercise (e.g., public health dose), a testable hypothesis is that structured exercise is capable of improving psychiatric and somatic health in BD.
Mohammad T Alsuwaidan; Aaron Kucyi; Candy W Y Law; Roger S McIntyre
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neuromolecular medicine     Volume:  11     ISSN:  1559-1174     ISO Abbreviation:  Neuromolecular Med.     Publication Date:  2009  
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-03-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101135365     Medline TA:  Neuromolecular Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  328-36     Citation Subset:  IM    
Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
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MeSH Terms
Bipolar Disorder / physiopathology*,  therapy*
Endocannabinoids / physiology
Exercise Therapy*
Neuronal Plasticity / physiology
Neurotransmitter Agents / physiology
Oxidative Stress / physiology
Reg. No./Substance:
0/Endocannabinoids; 0/Neurotransmitter Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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