Document Detail

Exercise and Alzheimer's disease biomarkers in cognitively normal older adults.
MedLine Citation:
PMID:  20818789     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: In addition to the increasingly recognized role of physical exercise in maintaining cognition, exercise may influence Alzheimer's disease (AD) pathology, as transgenic mouse studies show lowered levels of AD pathology in exercise groups. The objective of this study was to elucidate the association between exercise and AD pathology in humans using Pittsburgh compound-B (PIB), amyloid-beta (Abeta)(42), tau, and phosphorylated tau (ptau)(181) biomarkers.
METHODS: Sixty-nine older adults (17 males, 52 females) aged 55 to 88 years, were recruited and confirmed to be cognitively normal. A questionnaire on physical exercise levels over the past decade was administered to all. Cerebrospinal fluid samples were collected from 56 participants, and amyloid imaging with PIB was performed on 54 participants.
RESULTS: Participants were classified based on biomarker levels. Those with elevated PIB (p = 0.030), tau (p = 0.040), and ptau(181) (p = 0.044) had significantly lower exercise, with a nonsignificant trend for lower Abeta(42) (p = 0.135) to be associated with less exercise. Results were similar for PIB after controlling for covariates; tau (p = 0.115) and ptau(181) (p = 0.123) differences were reduced to nonsignificant trends. Additional analyses also demonstrated that active individuals who met the exercise guidelines set by the American Heart Association had significantly lower PIB binding and higher Abeta(42) levels with and without controlling for covariates (PIB: p = 0.006 and p = 0.001; Abeta(42): p = 0.042 and p = 0.046). Last, the associations between exercise engagement and PIB levels were more prominent in APOE epsilon 4 noncarriers.
INTERPRETATION: Collectively, these results are supportive of an association between exercise engagement and AD biomarkers in cognitively normal older adults.
Kelvin Y Liang; Mark A Mintun; Anne M Fagan; Alison M Goate; Julie M Bugg; David M Holtzman; John C Morris; Denise Head
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Annals of neurology     Volume:  68     ISSN:  1531-8249     ISO Abbreviation:  Ann. Neurol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-06     Completed Date:  2010-09-24     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  311-8     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / cerebrospinal fluid*,  genetics,  prevention & control*,  radionuclide imaging
Amyloid beta-Peptides / cerebrospinal fluid*
Aniline Compounds / diagnostic use
Apolipoproteins E / genetics
Exercise / physiology*
Geriatric Assessment
Middle Aged
Peptide Fragments / cerebrospinal fluid*
Positron-Emission Tomography / methods
Psychiatric Status Rating Scales
Risk Factors
Thiazoles / diagnostic use
tau Proteins / blood,  cerebrospinal fluid*
Grant Support
5T32AG00030/AG/NIA NIH HHS; P01 AG003991/AG/NIA NIH HHS; P01 AG003991-28/AG/NIA NIH HHS; P01 AG026276/AG/NIA NIH HHS; P01 AG026276/AG/NIA NIH HHS; P01 AG026276-05/AG/NIA NIH HHS; P01 AG03991/AG/NIA NIH HHS; P50 AG005681/AG/NIA NIH HHS; P50 AG005681-28/AG/NIA NIH HHS; P50 AG05861/AG/NIA NIH HHS; T32 AG000030/AG/NIA NIH HHS; T32 AG000030-35/AG/NIA NIH HHS; T32 GM081739/GM/NIGMS NIH HHS
Reg. No./Substance:
0/2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; 0/Amyloid beta-Peptides; 0/Aniline Compounds; 0/Apolipoproteins E; 0/Peptide Fragments; 0/Thiazoles; 0/amyloid beta-protein (1-42); 0/tau Proteins
Comment In:
Ann Neurol. 2010 Sep;68(3):275-6   [PMID:  20818785 ]

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