| Exercise After Traumatic Brain Injury: Is it a Double-Edged Sword? | |
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MedLine Citation:
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PMID: 21703583 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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This article describes the effects of exercise on neural plasticity after traumatic brain injury (TBI). There is strong evidence that indicates that exercise has neuroprotective effects by activating specific neuronal circuits and increasing molecules that enhance synaptic plasticity. Findings obtained from experimental models of TBI are discussed to support the use of exercise as a rehabilitative tool. These studies indicate that injury characteristics are likely to influence the time window for therapeutic exercise. Results of human and animal studies suggest that premature postconcussive exercise may be deleterious by exacerbating postconcussive symptomatology and disrupting restorative processes. A better understanding of the mechanisms that influence exercise after TBI will contribute to improving guidelines for the return to exercise activities and to the successful use of exercise as a therapeutic tool. |
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Authors:
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Grace S Griesbach |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: PM & R : the journal of injury, function, and rehabilitation Volume: 3 ISSN: 1934-1563 ISO Abbreviation: PM R Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101491319 Medline TA: PM R Country: United States |
Other Details:
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Languages: eng Pagination: S64-72 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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UCLA Brain Injury Research Center, University of California at Los Angeles, Los Angeles, CA; Department of Neurosurgery, Box 957030, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-7039(⁎). |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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