Document Detail

Exenatide and feeding: possible peripheral neuronal pathways.
MedLine Citation:
PMID:  22222610     Owner:  NLM     Status:  MEDLINE    
Intraperitoneal (i.p.) administration of the synthetic agonist of the glucagon like peptide-1 (GLP-1) receptor exenatide reduces food intake. Here, we evaluated possible peripheral pathways for this reduction. Exenatide (0.5 μg/kg, i.p.) was given to three, overnight food-deprived, groups of rats: total subdiaphragmatic vagotomy (VGX, severs the vagus nerve), celiaco-mesenteric ganglionectomy (CMGX, severs the splanchnic nerve) and combined VGX/CMGX. Following the injection, meal sizes (MSs) and intermeal intervals (IMIs) were determined for a total of 120 min. We found that exenatide reduced the sizes of the first two meals but failed to prolong the IMI between them, that VGX attenuated the reduction of the first MS, and that VGX, CMGX and combined VGX/CMGX attenuated the reduction of the second MS by exenatide. Therefore, the vagus nerve appears necessary for the reduction of the first MS by exenatide, whereas both nerves appear necessary for the reduction of the second MS by this peptide.
Jizette V Hunt; Martha C Washington; Ayman I Sayegh
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-12-24
Journal Detail:
Title:  Peptides     Volume:  33     ISSN:  1873-5169     ISO Abbreviation:  Peptides     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-28     Completed Date:  2012-06-19     Revised Date:  2014-05-09    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  285-90     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Appetite Depressants / pharmacology*
Appetite Regulation / drug effects*
Eating / drug effects*
Gastrointestinal Tract / innervation
Peptides / pharmacology*
Rats, Sprague-Dawley
Splanchnic Nerves / drug effects*
Vagus Nerve / drug effects*
Venoms / pharmacology*
Grant Support
Reg. No./Substance:
0/Appetite Depressants; 0/Peptides; 0/Venoms; 9P1872D4OL/exenatide

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