| Exenatide and Sitagliptin Are Not Associated with Increased Risk of Acute Renal Failure: A Retrospective Claims Analysis. | |
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MedLine Citation:
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PMID: 22268550 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective This study evaluated whether the risk of acute renal failure (ARF) increases with exenatide and sitagliptin use. Research Design and Methods A retrospective cohort study of a large medical and pharmacy claims database was performed. Data for 491,539 patients were analyzed. Cox proportional hazard models were used to compare the risk of ARF between diabetic and non-diabetic subjects and between diabetic patients treated with exenatide, sitagliptin and control medications. Results Adjusted Cox analyses demonstrated diabetic subjects had a higher risk of ARF (HR 1.51, CI 1.26-1.81, p<0.001) than nondiabetic controls. Compared with diabetic controls, neither exenatide (HR 0.77, CI 0.42- 1.41, p = 0.40) nor sitagliptin (HR 1.17, CI 0.82-1.65, p=0.39) increased the risk of ARF. Conclusion Our study revealed an increased incidence of ARF in diabetic versus non-diabetic patients but no association between use of exenatide or sitagliptin and ARF. Due to the limitations of this observational analysis, we cannot exclude the possibility of a very small increased risk. |
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Authors:
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Merri Pendergrass; Cynthia Fenton; Steven M Haffner; William Chen |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-23 |
Journal Detail:
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Title: Diabetes, obesity & metabolism Volume: - ISSN: 1463-1326 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883645 Medline TA: Diabetes Obes Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 Blackwell Publishing Ltd. |
Affiliation:
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Medco Health Solutions, Franklin Lakes, NJ 07417 University of Texas Southwestern Medical Center, Dallas, TX 75235 University of California, San Francisco, CA 94143 San Antonio, TX 78230. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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