Document Detail

Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging.
MedLine Citation:
PMID:  22343510     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this article is to summarize the recommended updates to the 2001 Stages of Reproductive Aging Workshop (STRAW) criteria. The 2011 STRAW + 10 reviewed advances in understanding of the critical changes in hypothalamic-pituitary-ovarian function that occur before and after the final menstrual period.
METHODS: Scientists from five countries and multiple disciplines evaluated data from cohort studies of midlife women and in the context of chronic illness and endocrine disorders on change in menstrual, endocrine, and ovarian markers of reproductive aging including antimüllerian hormone, inhibin-B, follicle-stimulating hormone, and antral follicle count. Modifications were adopted by consensus.
RESULTS: STRAW + 10 simplified bleeding criteria for the early and late menopausal transition, recommended modifications to criteria for the late reproductive stage (Stage -3) and the early postmenopause stage (Stage +1), provided information on the duration of the late transition (Stage -1) and early postmenopause (Stage +1), and recommended application regardless of women's age, ethnicity, body size, or lifestyle characteristics.
CONCLUSIONS: STRAW + 10 provides a more comprehensive basis for assessing reproductive aging in research and clinical contexts. Application of the STRAW + 10 staging system should improve comparability of studies of midlife women and facilitate clinical decision making. Nonetheless, important knowledge gaps persist, and seven research priorities are identified.
Siobán D Harlow; Margery Gass; Janet E Hall; Roger Lobo; Pauline Maki; Robert W Rebar; Sherry Sherman; Patrick M Sluss; Tobie J de Villiers;
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Menopause (New York, N.Y.)     Volume:  19     ISSN:  1530-0374     ISO Abbreviation:  Menopause     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-28     Completed Date:  2012-08-01     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  9433353     Medline TA:  Menopause     Country:  United States    
Other Details:
Languages:  eng     Pagination:  387-95     Citation Subset:  IM    
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MeSH Terms
Aging / metabolism*
Anti-Mullerian Hormone / metabolism
Biological Markers / metabolism
Biomedical Research
Cohort Studies
Congresses as Topic
Endocrine System Diseases / metabolism*
Hypothalamo-Hypophyseal System / metabolism*
Menopause / metabolism*
Ovary / metabolism
Reproduction / physiology
Women's Health*
Grant Support
AG039961/AG/NIA NIH HHS; R13 AG039961/AG/NIA NIH HHS; R13 AG039961-01A1/AG/NIA NIH HHS; R24 HD041028/HD/NICHD NIH HHS
Reg. No./Substance:
0/Biological Markers; 80497-65-0/Anti-Mullerian Hormone
Siobán D Harlow / ; Margery Gass / ; Janet E Hall / ; Roger Lobo / ; Pauline Maki / ; Robert W Rebar / ; Sherry Sherman / ; Tobie J de Villiers / ; Susan E Appt / ; Valerie L Baker / ; Frank J Broekmans / ; Marcelle I Cedars / ; Ruth Greenblatt / ; Sybil Crawford / ; Lynnette L Sievert / ; Lorraine Dennerstein / ; Ellen W Freeman / ; Mary Sammel / ; Marjorie Gass / ; Georgina Hale / ; Karl R Hall / ; Siobán D Harlow / ; Rod Little / ; Pangaja Paramsothy / ; John F Randolph / ; Nicole Jaff / ; Hadine Joffe / ; Jan Shifren / ; Patrick M Sluss / ; Roger Lobo / ; Michelle Warren / ; Pauline Maki / ; Kathleen O'Connor / ; Nancy Fugate Woods / ; Robert Rebar / ; Gloria Richard-Davis / ; David M Robertson / ; Sherry Sherman / ; Claudio N Soares / ; H Irene Su / ; Josefina Romaguera / ; Wulf Utian / ; Heidi VandenBrink / ; Tobie J de Villiers / ; Miriam T Weber / ; Melissa F Wellons /

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