Document Detail

Excretory urography by intraosseous injection of contrast media in a rabbit model.
MedLine Citation:
PMID:  11405266     Owner:  NLM     Status:  MEDLINE    
There are many indications for an intravenous excretory urogram. However, where intravenous access is not available, the intraosseous route to the circulation may be an alternative. We found that safe and diagnostic excretory urograms could be obtained in rabbits following the injection of different contrast media via the intraosseous route. In fact, these excretory urograms were indistinguishable from ones obtained by the conventional intravenous route. While the rabbits did not develop any abnormal clinical signs following the procedure, there were postmortem histologic lesions of osteochondrosis in 5 of 22 (22.7%) tibias receiving an intraosseous needle, but in none of the 14 tibias that did not receive an intraosseous needle. Further, the use of diatrizoate was associated with the development of osteochondrosis while the use of iopamidol was not.
P Porzio; J W Pharr; A L Allen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association     Volume:  42     ISSN:  1058-8183     ISO Abbreviation:  Vet Radiol Ultrasound     Publication Date:    2001 May-Jun
Date Detail:
Created Date:  2001-06-14     Completed Date:  2001-10-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9209635     Medline TA:  Vet Radiol Ultrasound     Country:  United States    
Other Details:
Languages:  eng     Pagination:  238-43     Citation Subset:  IM    
Department of Veterinary Internal Medicine, Western College of Veterinary Medicine, University of Saskatchewan, Canada.
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MeSH Terms
Contrast Media / administration & dosage*,  adverse effects
Diatrizoate / administration & dosage*,  adverse effects
Injections / veterinary
Injections, Intravenous / veterinary
Iothalamic Acid / administration & dosage*,  adverse effects
Models, Animal
Osteochondritis / etiology*
Prospective Studies
Specific Pathogen-Free Organisms
Urinary Tract Physiological Phenomena*
Urography / veterinary*
Reg. No./Substance:
0/Contrast Media; 117-96-4/Diatrizoate; 2276-90-6/Iothalamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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