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Excretion patterns of large and small proteins in preeclamptic pregnancies.
MedLine Citation:
PMID:  21542812     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective. Preeclampsia is a serious pregnancy complication causing both fetal and maternal distress. Proteinuria is a diagnostic criterion frequently determined by albuminuria. We determined the protein excretion pattern of alternative proteins IgG, transferrin, α1-microglobulin and β2-microglobulin in urines collected prospectively during preeclamptic and healthy pregnancies. Design. A prospective cohort study of 1 631 consecutive, pregnant women. Setting. A Danish Regional Hospital. Samples. Thirty two women with preeclampsia and 185 healthy controls were identified from the cohort. Urine samples were obtained from the 18(th) week until delivery and divided into 6 gestational intervals. Method. Protein analyses of urine IgG, transferrin, α1-microglobulin and β2-microglobulin were done with a sandwich ELISA method. Main outcome measures. Urine levels of specific proteins during preeclamptic and healthy pregnancies. Results. IgG and transferrin were significantly increased in preeclampsia after the 30(th) week of pregnancy. Alpha(1) -microglobulin and β(2) -microglobulin were differently excreted and found higher after the 36(th) week of pregnancy in preeclampsia, but only α1-microglobulin increased significantly. Conclusion. IgG, transferrin, α1- and β2-microglobulin excretion patterns indicate initial glomerular damage followed by altered tubular handling of proteins.
Authors:
Camilla Kronborg; Erik Vittinghus; Jim Allen; Ulla Breth Knudsen
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-4
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  -     ISSN:  1600-0412     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors AOGS© 2011 Nordic Federation of Societies of Obstetrics and Gynecology.
Affiliation:
Department of Gynecology and Obstetrics, and Department of Clinical Biochemistry, Randers County Hospital, Randers, Denmark.
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