Document Detail


Excretion of cytomegalovirus in mothers: observations after delivery of congenitally infected and normal infants.
MedLine Citation:
PMID:  6282987     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Shedding of cytomegalovirus (CMV) was studied in 142 women who gave birth to congenitally infected infants and in 81 seropositive control mothers (mothers of uninfected infants). Viral cultures from the throat, vagina, and urine were obtained at intervals between one month and nearly 12 years after delivery. In both groups the prevalence of excretion of CMV was greater in younger women and fell to low levels by age 30. Considering all of the sites of infection, 60% of the mothers of infected infants were shedding CMV within the first three months post partum compared with 18% of the control mothers; CMV shedding rates declined during the first 12 months post partum to 35% in the former group and to 3% in the latter. More than three years after delivery, seven (15%) of 45 mothers who transmitted CMV still had viruria. The excretion of CMV is common and persistent in mothers of children with congenital infections due to CMV.
Authors:
R F Pass; S Stagno; M E Dworsky; R J Smith; C A Alford
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  146     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-08-26     Completed Date:  1982-08-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Cytomegalovirus / isolation & purification*
Cytomegalovirus Infections / congenital,  microbiology*,  transmission,  urine
Female
Humans
Infant, Newborn
Pharynx / microbiology
Pregnancy
Pregnancy Complications, Infectious* / microbiology
Socioeconomic Factors
Vagina / microbiology
Grant Support
ID/Acronym/Agency:
5-MO1-RR32/RR/NCRR NIH HHS; HD-106999/HD/NICHD NIH HHS; T32-A107041//PHS HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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