Document Detail


Exclusion testing for Huntington's disease in pregnancy with a closely linked DNA marker.
MedLine Citation:
PMID:  2884411     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
55 couples where one partner was at 50% risk of Huntington's disease (HD) were investigated with a DNA probe closely linked to HD, with a view to exclusion testing in a future pregnancy. In 3 of 9 pregnancies so far, HD was excluded in the absence of recombination. In 3 the risk was raised to around 50%, and in 2 exclusion tests were uninformative. The remaining couple changed their minds about termination of the pregnancy and the test was therefore judged inappropriate.
Authors:
O W Quarrell; A L Meredith; A Tyler; S Youngman; M Upadhyaya; P S Harper
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lancet     Volume:  1     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-07-10     Completed Date:  1987-07-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1281-3     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Chorionic Villi / analysis
DNA / analysis*
Female
Genetic Markers*
Haplotypes
Humans
Huntington Disease / diagnosis*
Male
Pregnancy
Prenatal Diagnosis / methods*
Risk
Chemical
Reg. No./Substance:
0/Genetic Markers; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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