| Exclusion testing for Huntington's disease in pregnancy with a closely linked DNA marker. | |
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MedLine Citation:
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PMID: 2884411 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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55 couples where one partner was at 50% risk of Huntington's disease (HD) were investigated with a DNA probe closely linked to HD, with a view to exclusion testing in a future pregnancy. In 3 of 9 pregnancies so far, HD was excluded in the absence of recombination. In 3 the risk was raised to around 50%, and in 2 exclusion tests were uninformative. The remaining couple changed their minds about termination of the pregnancy and the test was therefore judged inappropriate. |
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Authors:
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O W Quarrell; A L Meredith; A Tyler; S Youngman; M Upadhyaya; P S Harper |
Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Lancet Volume: 1 ISSN: 0140-6736 ISO Abbreviation: Lancet Publication Date: 1987 Jun |
Date Detail:
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Created Date: 1987-07-10 Completed Date: 1987-07-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985213R Medline TA: Lancet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1281-3 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chorionic Villi
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analysis DNA / analysis* Female Genetic Markers* Haplotypes Humans Huntington Disease / diagnosis* Male Pregnancy Prenatal Diagnosis / methods* Risk |
| Chemical | |
Reg. No./Substance:
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0/Genetic Markers; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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