Document Detail


Exclusion of linkage between schizophrenia and the gene encoding a neutral amino acid glutamate/aspartate transporter, SLC1A5.
MedLine Citation:
PMID:  9034006     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An abnormality in glutamatergic function has been hypothesized as being of etiological importance in schizophrenia. Twenty-three multiplex English and Icelandic schizophrenia families were genotyped with a polymorphic dinucleotide repeat sequence in the 3'-untranslated region of the glutamate/aspartate transporter gene called SLC1A5. Using the lod and a model-free method of linkage analysis (MFLINK), no evidence of linkage between SLC1A5 and schizophrenia was found. Our results do not support the hypothesis that SLC1A5 gene mutations or allelic variants provide a major gene contribution to the etiology of schizophrenia. However, because of the likelihood of heterogeneity of linkage in schizophrenia, there is a case for testing other pedigrees for linkage to the SLC1A5 locus. The SLC1A5 locus is one of a complex family of genes encoding neutral amino acid transporter proteins and the genetic relation between these other loci and schizophrenia has not yet been established.
Authors:
A C Chen; G Kalsi; J Brynjolfsson; T Sigmundsson; D Curtis; R Butler; T Read; P Murphy; E A Barnard; H Petursson; H M Gurling
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of medical genetics     Volume:  74     ISSN:  0148-7299     ISO Abbreviation:  Am. J. Med. Genet.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-04-30     Completed Date:  1997-04-30     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  7708900     Medline TA:  Am J Med Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  50-2     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, University College London Medical School, UK.
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MeSH Terms
Descriptor/Qualifier:
Alleles
Amino Acid Transport System X-AG
Carrier Proteins / genetics*
England
Female
Genetic Markers
Genotype
Glycoproteins / genetics*
Humans
Iceland
Linkage (Genetics)*
Lod Score
Male
Pedigree
Polymerase Chain Reaction
Recombination, Genetic
Schizophrenia / genetics*,  metabolism
Software
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/Amino Acid Transport System X-AG; 0/Carrier Proteins; 0/Genetic Markers; 0/Glycoproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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