Document Detail

Exclusion of linkage between schizophrenia and the gene encoding a neutral amino acid glutamate/aspartate transporter, SLC1A5.
MedLine Citation:
PMID:  9034006     Owner:  NLM     Status:  MEDLINE    
An abnormality in glutamatergic function has been hypothesized as being of etiological importance in schizophrenia. Twenty-three multiplex English and Icelandic schizophrenia families were genotyped with a polymorphic dinucleotide repeat sequence in the 3'-untranslated region of the glutamate/aspartate transporter gene called SLC1A5. Using the lod and a model-free method of linkage analysis (MFLINK), no evidence of linkage between SLC1A5 and schizophrenia was found. Our results do not support the hypothesis that SLC1A5 gene mutations or allelic variants provide a major gene contribution to the etiology of schizophrenia. However, because of the likelihood of heterogeneity of linkage in schizophrenia, there is a case for testing other pedigrees for linkage to the SLC1A5 locus. The SLC1A5 locus is one of a complex family of genes encoding neutral amino acid transporter proteins and the genetic relation between these other loci and schizophrenia has not yet been established.
A C Chen; G Kalsi; J Brynjolfsson; T Sigmundsson; D Curtis; R Butler; T Read; P Murphy; E A Barnard; H Petursson; H M Gurling
Related Documents :
19245826 - Do schizophrenia and bipolar disorders share a common disease susceptibility variant at...
11407996 - The (ctg)n polymorphism in the notch4 gene is not associated with schizophrenia in japa...
8178826 - Evidence for anticipation in schizophrenia.
8886166 - Dopamine drd2/cys311 is not associated with chronic schizophrenia.
7635296 - Mu1-related transposable elements of maize preferentially insert into low copy number dna.
9549246 - Molecular approaches to child psychopathology.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of medical genetics     Volume:  74     ISSN:  0148-7299     ISO Abbreviation:  Am. J. Med. Genet.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-04-30     Completed Date:  1997-04-30     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  7708900     Medline TA:  Am J Med Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  50-2     Citation Subset:  IM    
Department of Psychiatry, University College London Medical School, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amino Acid Transport System X-AG
Carrier Proteins / genetics*
Genetic Markers
Glycoproteins / genetics*
Linkage (Genetics)*
Lod Score
Polymerase Chain Reaction
Recombination, Genetic
Schizophrenia / genetics*,  metabolism
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Amino Acid Transport System X-AG; 0/Carrier Proteins; 0/Genetic Markers; 0/Glycoproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Screening the monoamine oxidase B gene in 100 male patients with schizophrenia: a cluster of polymor...
Next Document:  Genotypic association between dopamine transporter gene polymorphisms and schizophrenia.