Document Detail


Exclusion of linkage of Crohn's disease to previously reported regions on chromosomes 12, 7, and 3 in the Belgian population indicates genetic heterogeneity.
MedLine Citation:
PMID:  10961588     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Susceptibility to inflammatory bowel disease (IBD) is significantly determined by genetic factors. Linkage data from genome-wide searches have identified regions on chromosomes 16, 12, 7, and 3. Our goal was to replicate these four regions in a Belgian population of IBD families. Fifty-four IBD families were studied (47 with Crohn's disease [CD] and 7 with mixed CD and ulcerative colitis, containing 79 affected sibpairs (68 CD only, 11 mixed) for the regions previously implicated to chromosomes 16, 12, 7, and 3. In this study, no evidence for linkage was found on any of the four chromosomal regions studied for either the whole IBD dataset or the CD subgroup. The multipoint maximum logarithm of odds scores were less than 0.7 for all four regions. Exclusion mapping could significantly exclude chromosomes 3, 7, and 12. Despite earlier findings, we could significantly exclude linkage of CD with previously reported regions on chromosomes 12, 7, and 3, and could not find evidence for linkage to chromosome 16. It is important to report these findings in light of the genetic heterogeneity of IBD. A genome-wide search on a larger group of affected siblings is being analyzed to detect other possible susceptibility loci in the Belgian population.
Authors:
S Vermeire; M Peeters; R Vlietinck; M Parkes; J Satsangi; D Jewell; P Rutgeerts
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Inflammatory bowel diseases     Volume:  6     ISSN:  1078-0998     ISO Abbreviation:  Inflamm. Bowel Dis.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-12-04     Completed Date:  2000-12-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9508162     Medline TA:  Inflamm Bowel Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  165-70     Citation Subset:  IM    
Affiliation:
Gastroenterology Unit, University Hospital Gasthuisberg, Leuven, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Belgium / epidemiology
Chromosomes, Human, Pair 12 / genetics*
Chromosomes, Human, Pair 3 / genetics*
Chromosomes, Human, Pair 7 / genetics*
Crohn Disease / epidemiology,  genetics*
Female
Genetic Predisposition to Disease
Genetic Variation / genetics*
Genetics, Population
Humans
Linkage (Genetics) / genetics*
Male
Pedigree

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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