| Excitatory synaptic transmission in the lateral and central amygdala. | |
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MedLine Citation:
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PMID: 12724149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The amygdala plays a major role in the acquisition and expression of fear conditioning. NMDA receptor-dependent synaptic plasticity within the basolateral amygdala has been proposed to underlie the acquisition and possible storage of fear memories. Here the properties of fast glutamatergic transmission in the lateral and central nuclei of the amygdala are presented. In the lateral amygdala, two types of neurons, interneurons and projection neurons, could be distinguished by their different firing properties. Glutamatergic inputs to interneurons activated AMPA receptors with inwardly rectifying current-voltage relations (I-Vs), whereas inputs to projection neurons activated receptors that had linear I-Vs, indicating that receptors on interneurons lack GluR2 subunits. Inputs to projection neurons formed dual component synapses with both AMPA and NMDA components, whereas at inputs to interneurons, the contribution of NMDA receptors was very small. Neurons in the central amygdala received dual component glutamatergic inputs that activated AMPA receptors with linear I-Vs. NMDA receptor-mediated EPSCs had slow decay time constants in the central nucleus. Application of NR2B selective blockers ifenprodil or CP-101,606 blocked NMDA EPSCs by 70% in the central nucleus, but only by 30% in the lateral nucleus. These data show that the distribution of glutamatergic receptors on amygdalar neurons is not uniform. In the lateral amygdala, interneurons and pyramidal neurons express AMPA receptors with different subunit compositions. Synapses in the central nucleus activate NMDA receptors that contain NR1 and NR2B subunits, whereas synapses in the lateral nucleus contain receptors with both NR2A and NR2B subunits. |
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Authors:
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P Sah; Mikel Lopez De Armentia |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 985 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-05-01 Completed Date: 2003-06-17 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 67-77 Citation Subset: IM |
Affiliation:
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Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia. pankaj.sah@anu.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amygdala
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anatomy & histology,
physiology* Animals Evoked Potentials / physiology Evoked Potentials, Somatosensory / physiology Long-Term Potentiation Neurons / physiology Rats Rats, Wistar Receptors, AMPA / physiology Receptors, N-Methyl-D-Aspartate / physiology Synaptic Transmission / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, AMPA; 0/Receptors, N-Methyl-D-Aspartate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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