Document Detail


Excitatory synaptic potentials in spastic human motoneurons have a short rise-time.
MedLine Citation:
PMID:  15786417     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study assessed whether changes in size or time-course of excitatory postsynaptic potentials (EPSPs) in motoneurons innervating spastic muscle could induce a greater synaptic response, and thereby contribute to reflex hyperexcitability. We compared motor unit (MU) firing patterns elicited by tendon taps applied to both spastic and contralateral (nonspastic) biceps brachii muscle in hemiparetic stroke subjects. Based on recordings of 115 MUs, significantly shortened EPSP rise times were present on the spastic side, but with no significant differences in estimated EPSP amplitude. These changes may contribute to hyperexcitable reflex responses at short latency, but the EPSP amplitude changes appear insufficient to account for global differences in reflex excitability.
Authors:
Nina L Suresh; Michael D Ellis; Jennifer Moore; Heather Heckman; William Zev Rymer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Muscle & nerve     Volume:  32     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-06-22     Completed Date:  2005-08-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  99-103     Citation Subset:  IM    
Affiliation:
Sensory Motor Performance Program, Rehabilitation Institute of Chicago, 345 East Superior Street, Suite 1406, Chicago, Illinois 60611, USA. n-suresh@northwestern.edu
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MeSH Terms
Descriptor/Qualifier:
Excitatory Postsynaptic Potentials / physiology*
Humans
Middle Aged
Motor Neurons / physiology*
Muscle Spasticity / physiopathology*
Paresis / diagnosis,  physiopathology*
Stroke / diagnosis,  physiopathology*
Tendons / innervation,  physiology
Grant Support
ID/Acronym/Agency:
1R24 HD39627-01/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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