Document Detail


Excitatory, inhibitory and facilitatory frequency response areas in the inferior colliculus of hearing impaired mice.
MedLine Citation:
PMID:  17412539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Individuals with age-related hearing loss often have difficulty understanding complex sounds such as basic speech. The C57BL/6 mouse suffers from progressive sensorineural hearing loss and thus is an effective tool for dissecting the neural mechanisms underlying changes in complex sound processing observed in humans. Neural mechanisms important for processing complex sounds include multiple tuning and combination sensitivity, and these responses are common in the inferior colliculus (IC) of normal hearing mice. We examined neural responses in the IC of C57Bl/6 mice to single and combinations of tones to examine the extent of spectral integration in the IC after age-related high frequency hearing loss. Ten percent of the neurons were tuned to multiple frequency bands and an additional 10% displayed non-linear facilitation to the combination of two different tones (combination sensitivity). No combination-sensitive inhibition was observed. By comparing these findings to spectral integration properties in the IC of normal hearing CBA/CaJ mice, we suggest that high frequency hearing loss affects some of the neural mechanisms in the IC that underlie the processing of complex sounds. The loss of spectral integration properties in the IC during aging likely impairs the central auditory system's ability to process complex sounds such as speech.
Authors:
Richard A Felix; Christine V Portfors
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-03-02
Journal Detail:
Title:  Hearing research     Volume:  228     ISSN:  0378-5955     ISO Abbreviation:  Hear. Res.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-04     Completed Date:  2007-07-03     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  212-29     Citation Subset:  IM    
Affiliation:
School of Biological Sciences, Washington State University, 14204 NE Salmon Creek Avenue, Vancouver, WA 98686, United States.
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Aging
Animals
Auditory Perception*
Auditory Threshold
Cochlear Nerve / pathology,  physiopathology*
Disease Models, Animal
Evoked Potentials, Auditory, Brain Stem*
Fourier Analysis
Inferior Colliculi / pathology,  physiopathology*
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Neural Inhibition*
Neuronal Plasticity*
Presbycusis / pathology,  physiopathology*
Grant Support
ID/Acronym/Agency:
R01 DC004733-04S1/DC/NIDCD NIH HHS; R01 DC004733-05/DC/NIDCD NIH HHS; R01 DC04733/DC/NIDCD NIH HHS
Comments/Corrections

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