Document Detail

Excitatory and inhibitory amino acid levels in the cerebrospinal fluids of children with neurological disorders.
MedLine Citation:
PMID:  10910589     Owner:  NLM     Status:  MEDLINE    
Measurement of amino acid levels in the cerebrospinal fluid (CSF) of children with various neurological disorders was performed with high performance liquid chromatography (HPLC). Glutamate increased in patients with bacterial meningitis, aseptic meningitis and encephalitis. Aspartate increased in bacterial meningitis and seizure disorders. Glycine increased in both bacterial and aseptic meningitis. Taurine increased in bacterial meningitis and encephalitis. GABA, the main inhibitory amino acid, increased in encephalitis. Excitatory and inhibitory amino acids are richly distributed in brain tissue and are related to neuron activity. Changes in amino acid levels in the CSF may reflect the pathologic state and severity of brain insults, and may be useful in monitoring disease processes. Further study is necessary to determine whether CSF aminos acid levels have a role in practical clinical application.
E Y Shen; Y J Lai; C S Ho; Y L Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi     Volume:  40     ISSN:  1608-8115     ISO Abbreviation:  Acta Paediatr Taiwan     Publication Date:    1999 Mar-Apr
Date Detail:
Created Date:  1999-06-15     Completed Date:  1999-06-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100958202     Medline TA:  Acta Paediatr Taiwan     Country:  CHINA (REPUBLIC : 1949-)    
Other Details:
Languages:  eng     Pagination:  65-9     Citation Subset:  IM    
Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.
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MeSH Terms
Amino Acids / cerebrospinal fluid*
Biological Markers
Case-Control Studies
Encephalitis / cerebrospinal fluid*
Excitatory Amino Acids / cerebrospinal fluid
Meningitis / cerebrospinal fluid*
Neurotransmitter Agents / cerebrospinal fluid*
Seizures / cerebrospinal fluid*
Reg. No./Substance:
0/Amino Acids; 0/Biological Markers; 0/Excitatory Amino Acids; 0/Neurotransmitter Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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