Document Detail


Excitatory amino acids and monoaminergic neurotransmitters in cerebrospinal fluid of acute ischemic stroke patients.
MedLine Citation:
PMID:  20036703     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Improved insight in the role of neurotransmitters in acute cerebral ischemic injury may be fundamental for the successful development of novel therapeutic approaches. We investigated excitatory amino acids and monoaminergic neurotransmitters in cerebrospinal fluid (CSF) of acute ischemic stroke patients and their relation to stroke characteristics.
METHODS: CSF concentrations of glutamate, aspartate, glutamine, glycine, proline, taurine, norepinephrine, 5-hydroxyindoleacetic acid, homovanillic acid and 3,4-dihydroxyphenylacetic acid were assessed in 89 stroke patients at admission (median 6.3h after stroke onset) and in 31 controls. We evaluated the relation between CSF concentrations and (a) stroke severity (NIHSS score at admission, lesion volume), (b) stroke evolution in the subacute phase, (c) long-term stroke outcome, (d) lesion location, and (e) stroke etiology.
RESULTS: Neurotransmitter systems display relevant interrelations, however, no significant associations between neurotransmitter concentrations in CSF and stroke characteristics were found, with the exception of higher 5-hydroxyindoleacetic acid levels in CSF of patients with progressing stroke and poor long-term outcome.
CONCLUSIONS: The study results question the added value of neurotransmitter assessment in CSF for research on ischemic cerebral injury.
Authors:
Raf Brouns; An Van Hemelrijck; Wilhelmus H Drinkenburg; Debby Van Dam; Didier De Surgeloose; Peter P De Deyn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-29
Journal Detail:
Title:  Neurochemistry international     Volume:  56     ISSN:  1872-9754     ISO Abbreviation:  Neurochem. Int.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-05-18     Completed Date:  2010-11-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006959     Medline TA:  Neurochem Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  865-70     Citation Subset:  IM    
Copyright Information:
2009 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Neurology and Memory Clinic, ZNA Middelheim Hospital, Antwerp, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Aged
Aged, 80 and over
Biogenic Monoamines / cerebrospinal fluid*
Biological Markers / cerebrospinal fluid
Brain Chemistry / physiology
Brain Ischemia / cerebrospinal fluid*,  etiology,  pathology
Disease Progression
Excitatory Amino Acids / cerebrospinal fluid*
Female
Humans
Male
Neurotransmitter Agents / cerebrospinal fluid*
Severity of Illness Index
Spinal Puncture
Stroke / cerebrospinal fluid*,  etiology,  pathology
Time
Chemical
Reg. No./Substance:
0/Biogenic Monoamines; 0/Biological Markers; 0/Excitatory Amino Acids; 0/Neurotransmitter Agents

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