| Excitatory amino acids and monoaminergic neurotransmitters in cerebrospinal fluid of acute ischemic stroke patients. | |
| | |
MedLine Citation:
|
PMID: 20036703 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND PURPOSE: Improved insight in the role of neurotransmitters in acute cerebral ischemic injury may be fundamental for the successful development of novel therapeutic approaches. We investigated excitatory amino acids and monoaminergic neurotransmitters in cerebrospinal fluid (CSF) of acute ischemic stroke patients and their relation to stroke characteristics. METHODS: CSF concentrations of glutamate, aspartate, glutamine, glycine, proline, taurine, norepinephrine, 5-hydroxyindoleacetic acid, homovanillic acid and 3,4-dihydroxyphenylacetic acid were assessed in 89 stroke patients at admission (median 6.3h after stroke onset) and in 31 controls. We evaluated the relation between CSF concentrations and (a) stroke severity (NIHSS score at admission, lesion volume), (b) stroke evolution in the subacute phase, (c) long-term stroke outcome, (d) lesion location, and (e) stroke etiology. RESULTS: Neurotransmitter systems display relevant interrelations, however, no significant associations between neurotransmitter concentrations in CSF and stroke characteristics were found, with the exception of higher 5-hydroxyindoleacetic acid levels in CSF of patients with progressing stroke and poor long-term outcome. CONCLUSIONS: The study results question the added value of neurotransmitter assessment in CSF for research on ischemic cerebral injury. |
| | |
Authors:
|
Raf Brouns; An Van Hemelrijck; Wilhelmus H Drinkenburg; Debby Van Dam; Didier De Surgeloose; Peter P De Deyn |
Related Documents
:
|
15191883 - In vivo muscle amino acid transport involves two distinct processes. 2717653 - Amniotic fluid concentration of 5-hydroxyeicosatetraenoic acid is increased in human pa... 6167333 - Localization of axonally transported [3h]glycine in vesicles of identified neurons. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-12-29 |
Journal Detail:
|
Title: Neurochemistry international Volume: 56 ISSN: 1872-9754 ISO Abbreviation: Neurochem. Int. Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-05-18 Completed Date: 2010-11-29 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8006959 Medline TA: Neurochem Int Country: England |
Other Details:
|
Languages: eng Pagination: 865-70 Citation Subset: IM |
Copyright Information:
|
2009 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Department of Neurology and Memory Clinic, ZNA Middelheim Hospital, Antwerp, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Aged Aged, 80 and over Biogenic Monoamines / cerebrospinal fluid* Biological Markers / cerebrospinal fluid Brain Chemistry / physiology Brain Ischemia / cerebrospinal fluid*, etiology, pathology Disease Progression Excitatory Amino Acids / cerebrospinal fluid* Female Humans Male Neurotransmitter Agents / cerebrospinal fluid* Severity of Illness Index Spinal Puncture Stroke / cerebrospinal fluid*, etiology, pathology Time |
| Chemical | |
Reg. No./Substance:
|
0/Biogenic Monoamines; 0/Biological Markers; 0/Excitatory Amino Acids; 0/Neurotransmitter Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Linkage of hippocampal proteins to spatial memory formation and strain-dependence in Apodemus sylvat...
Next Document: Use of NAD(P)H and flavoprotein autofluorescence transients to probe neuron and astrocyte responses ...