Document Detail

Excitatory amino acids in cerebrospinal fluid following traumatic brain injury in humans.
MedLine Citation:
PMID:  8103092     Owner:  NLM     Status:  MEDLINE    
Evidence from models of traumatic brain injury implicates excitotoxicity as an integral process in the ultimate neuronal damage that follows. Concentrations of the excitatory amino acid glutamate were serially measured in the cerebrospinal fluid (CSF) of patients with traumatic brain injuries and in control patients for comparison. The purpose of the study was to determine whether glutamate concentrations were significantly elevated following traumatic brain injury and, if so, whether they were elevated in a time frame that would allow the use of antagonist therapy. Cerebrospinal fluid was sampled fresh from ventricular drains every 12 hours and analyzed using high-performance liquid chromatography for the excitatory amino acids. The peak concentrations of glutamate in the CSF of the 12 brain-injured patients ranged from 14 to 474 microM and were significantly higher than those in the three control patients, 4.9 to 17 microM (Mann-Whitney U-test, p < 0.02). Glutamate concentrations in five of the eight patients who were still being sampled on Day 3 were beyond the control group range. The implication of this study is that severely head-injured patients are exposed to high concentrations of a neurotoxic amino acid for days following injury and thus may benefit from antagonist intervention.
A J Baker; R J Moulton; V H MacMillan; P M Shedden
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  79     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-09-28     Completed Date:  1993-09-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  369-72     Citation Subset:  AIM; IM    
Department of Anaesthesia, University of Toronto, St. Michael's Hospital, Ontario, Canada.
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MeSH Terms
Brain Injuries / cerebrospinal fluid*
Glutamates / cerebrospinal fluid*
Glutamic Acid
Middle Aged
Osmolar Concentration
Reference Values
Reg. No./Substance:
0/Glutamates; 56-86-0/Glutamic Acid
Comment In:
J Neurosurg. 1994 Mar;80(3):595-6   [PMID:  7906728 ]

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