| Excitatory amino acid receptors in the dorsomedial hypothalamus are involved in the cardiovascular and behavioural chemoreflex responses. | |
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MedLine Citation:
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PMID: 20889605 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The present study investigated the role of the dorsomedial hypothalamus (DMH) on cardiovascular and behavioural responses of chemoreflex activation in conscious rats. The arterial chemoreflex was activated by potassium cyanide (KCN, 40 μg, i.v.) before and after bilateral microinjection of lidocaine (2%) or kynurenic acid (2.7 nmol) into the DMH. Locomotor activity was measured to assess the chemoreflex behavioural response. Bilateral microinjection of lidocaine into the DMH produced a significant reduction in the pressor response induced by chemoreflex activation (+51 ± 4 versus +34 ± 5 mmHg, n = 5, P < 0.05). A similar reduction in the pressor chemoreflex response was also observed after microinjection of kynurenic acid into the DMH (+50 ± 3 versus +22 ± 5 mmHg, n = 6, P < 0.05). Strikingly, the behaviour/locomotor activity induced by chemoreflex activation was virtually abolished after blockade of excitatory amino acid receptors in the DMH with kynurenic acid (44 ± 6 versus 5 ± 4 cm, n = 6, P < 0.05). There was no correlation between the reduction in pressor and behavioural chemoreflex responses (r = -0.186, P > 0.05). The bradycardic response of the chemoreflex was not altered by lidocaine or kynurenic acid microinjected into the DMH. These results strongly suggest that the excitatory amino acid receptors in the DMH are essential for full expression of the behavioural response of the chemoreflex and participate, at least in part, in the integration of the pressor response of the chemoreflex in conscious rats. |
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Authors:
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Edson Alexandre Queiroz; Marcos Noboru Okada; Ubirajara Fumega; Marco Antônio Peliky Fontes; Márcio Flávio Dutra Moraes; Andréa Siqueira Haibara |
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Publication Detail:
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Type: Journal Article Date: 2010-10-01 |
Journal Detail:
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Title: Experimental physiology Volume: 96 ISSN: 1469-445X ISO Abbreviation: Exp. Physiol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9002940 Medline TA: Exp Physiol Country: England |
Other Details:
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Languages: eng Pagination: 73-84 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, 31270-910, Belo Horizonte, MG, Brazil. haibara@icb.ufmg.br. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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