| Excitatory GABA: How a Correct Observation May Turn Out to be an Experimental Artifact. | |
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MedLine Citation:
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PMID: 22529813 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The concept of the excitatory action of GABA during early development is based on data obtained mainly in brain slice recordings. However, in vivo measurements as well as observations made in intact hippocampal preparations indicate that GABA is in fact inhibitory in rodents at early neonatal stages. The apparent excitatory action of GABA seems to stem from cellular injury due to the slicing procedure, which leads to accumulation of intracellular Cl(-) in injured neurons. This procedural artifact was shown to be attenuated through various manipulations such as addition of energy substrates more relevant to the in vivo situation. These observations question the very concept of excitatory GABA in immature neuronal networks. |
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Authors:
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Piotr Bregestovski; Christophe Bernard |
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Publication Detail:
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Type: Journal Article Date: 2012-04-19 |
Journal Detail:
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Title: Frontiers in pharmacology Volume: 3 ISSN: 1663-9812 ISO Abbreviation: Front Pharmacol Publication Date: 2012 |
Date Detail:
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Created Date: 2012-04-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101548923 Medline TA: Front Pharmacol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 65 Citation Subset: - |
Affiliation:
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INSERM URM 1106, Institut de Neuroscience des Systèmes, Aix-Marseille Université Marseille, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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