Document Detail

Excitation of phrenic and sympathetic output during acute hypoxia: contribution of medullary oxygen detectors.
MedLine Citation:
PMID:  10963768     Owner:  NLM     Status:  MEDLINE    
Severe brain hypoxia results in respiratory excitation and an increase in sympathetic nerve activity. Respiratory excitation takes the form of gasping which is characterized by an abrupt onset, high amplitude, short duration burst of inspiratory activity. Recent evidence suggests that centrally-mediated hypoxic respiratory and sympathetic excitation may result from direct hypoxic stimulation of discrete hypoxia chemosensitive sites in the medulla. Thus, medullary regions involved in the generation and modulation of respiratory and sympathetic vasomotor output may contain neurons which function as central oxygen detectors, acting as medullary analogs to the peripheral (arterial) chemoreceptors. This review focuses on the medullary sites and mechanisms proposed to mediate hypoxic respiratory and sympathetic excitation in anesthetized, chemodeafferented animals, and provides the evidence suggesting a role for central oxygen detectors in the control of breathing and sympathetic vasomotor output.
I C Solomon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Respiration physiology     Volume:  121     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-10-06     Completed Date:  2000-10-06     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  101-17     Citation Subset:  IM    
Department of Physiology and Biophysics, Health Sciences Center, Basic Science Tower, Level 6, Room 140, State University of New York at Stony Brook, Stony Brook, NY 11794-8661, USA.
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MeSH Terms
Anoxia / physiopathology*
Medulla Oblongata / physiopathology
Models, Biological
Oxygen / physiology
Phrenic Nerve / physiopathology*
Respiratory Physiological Phenomena
Sympathetic Nervous System / physiopathology*
Grant Support
Reg. No./Substance:

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