Document Detail

Excitation-contraction uncoupling in the rat diaphragm by 2,3-butanedione monoxime.
MedLine Citation:
PMID:  8243557     Owner:  NLM     Status:  MEDLINE    
2,3-Butanedione monoxime (BDM), 0.5-12.5 mM, inhibited the twitches rapidly and reversibly in the rat diaphragm. A more extensive inhibition at direct than at indirect stimulation, a simultaneous effect on the electromyogram, and an attenuation of the inhibitory effect in preparations made hyperexcitable with Ca(2+)-free solution, myotonia or veratridine, indicated an interference with the gating mechanism of the sarcolemma. The excitation-contraction uncoupling with BDM was additive to the similar effect of dantrolene. A synergistic effect was not found, and neither agent alone nor both in combination caused a complete excitation-contraction uncoupling. Several differences between the effects of BDM and dantrolene were disclosed: Lowering the temperature increased and decreased the effect of BDM and dantrolene, respectively. Tetanic stimulation and high Ca2+ or high K+ antagonized the effect of dantrolene and did not affect the BDM-induced inhibition. Ca(2+)-free solution potentiated the effect of dantrolene and antagonized the effect of BDM. Caffeine and KCl contractures were inhibited by BDM, whereas the propranolol contracture due to Na,K-ATPase inhibition, which is completely inhibited by dantrolene, was unaffected by BDM.
A Røed
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  241     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1994-01-06     Completed Date:  1994-01-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  229-36     Citation Subset:  IM    
Department of Oral Biology, Dental Faculty, University of Oslo, Blindern, Norway.
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MeSH Terms
Calcium / physiology
Dantrolene / pharmacology
Diacetyl / analogs & derivatives*,  pharmacology
Diaphragm / drug effects,  innervation
Drug Synergism
Muscle Contraction / drug effects*
Neuromuscular Junction / drug effects
Potassium / physiology
Reg. No./Substance:
431-03-8/Diacetyl; 57-71-6/diacetylmonoxime; 7261-97-4/Dantrolene; 7440-09-7/Potassium; 7440-70-2/Calcium

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