Document Detail

Excitation-contraction coupling and contractile protein function in failing and nonfailing human myocardium.
MedLine Citation:
PMID:  8184784     Owner:  NLM     Status:  MEDLINE    
Isometric force, heat output, and aequorin light emission were measured in isolated muscle strips from nonfailing human hearts and from hearts with endstage failing dilated cardiomyopathy (37 degrees C; 30-180 beats per minute (bpm)). In nonfailing myocardium, peak twitch tension increased with higher rates of stimulation, whereas the force-frequency relation was inverse in the failing myocardium. At 60 bpm and at higher rates of stimulation, peak twitch tension was reduced significantly in the failing myocardium. Myothermal measurements, performed at 60 bpm, indicated that the number of crossbridge interactions and the amount of calcium cycling are reduced significantly in the failing myocardium. Furthermore, aequorin light transients indicated that the inverse force-frequency relation in failing myocardium results from altered calcium cycling; with increasing rates of stimulation aequorin light emission increased continuously in the nonfailing and decreased continuously in the failing myocardium. The data suggest that impaired myocardial performance in failing human myocardium may result primarily from disturbed excitation-contraction coupling processes with a reduced amount of calcium cycling and, thus, a decreased activation of contractile proteins.
G Hasenfuss; B Pieske; C Holubarsch; N R Alpert; H Just
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  346     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  1993  
Date Detail:
Created Date:  1994-06-16     Completed Date:  1994-06-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  91-100     Citation Subset:  IM    
Medizinische Klinik III, Universität Freiburg, FRG.
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MeSH Terms
Calcium / metabolism
Cardiomyopathy, Dilated / metabolism,  physiopathology*
Contractile Proteins / physiology*
Myocardial Contraction / physiology*
Reference Values
Reg. No./Substance:
0/Contractile Proteins; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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