| Excitability of primary afferents in feline spinal cord: taurine, homotaurine, and gamma-aminobutyric acid compared. | |
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MedLine Citation:
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PMID: 7116229 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effects of taurine and homotaurine (3-aminopropanesulfonic acid), on excitability of primary afferents were compared with effects of gamma-aminobutyric acid (GABA) in spinal unanaesthesized cats. Homotaurine and GABA, administered intravenously or topically, produced a marked increase in afferent excitability. Homotaurine was about 10 times more potent than GABA. Taurine (up to 2 mmol/kg i.v., or 10 mM topically) did not produce a consistent change in afferent excitability. The effect of homotaurine was antagonized by bicuculline or picrotoxin in doses which suppressed the primary afferent depolarization, as indicated by an increase of afferent excitability, evoked by conditioning stimulation of an antagonistic muscle nerve. Semicarbazide, an inhibitor of GABA synthesis, did not attenuate the homotaurine-induced excitability changes of afferents while suppressing entirely the primary afferent depolarization. These findings suggest that homotaurine exerts a direct GABA-like action on feline primary afferents. |
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Authors:
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R Capek; B Esplin |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Canadian journal of physiology and pharmacology Volume: 60 ISSN: 0008-4212 ISO Abbreviation: Can. J. Physiol. Pharmacol. Publication Date: 1982 Jun |
Date Detail:
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Created Date: 1982-12-02 Completed Date: 1982-12-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372712 Medline TA: Can J Physiol Pharmacol Country: CANADA |
Other Details:
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Languages: eng Pagination: 850-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Afferent Pathways
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drug effects Animals Anticonvulsants / pharmacology* Cats Semicarbazides / pharmacology Spinal Cord / drug effects*, physiology Taurine / analogs & derivatives*, pharmacology* gamma-Aminobutyric Acid / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Semicarbazides; 107-35-7/Taurine; 3687-18-1/homotaurine; 56-12-2/gamma-Aminobutyric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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