Document Detail


Excision repair cross complementing 3 expression is involved in patient prognosis and tumor progression in esophageal cancer.
MedLine Citation:
PMID:  15375507     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The prognosis of patients with esophageal cancer remains poor. TNM classification is not sufficient to predict the prognosis. Therefore, novel predictive markers of the prognosis of esophageal cancer patients are awaited. The abnormality of the nucleotide excision repair (NER) is often involved in human cancers. Excision repair cross complementing 3 (ERCC3) contributes to NER. In esophageal cancer, ERCC3 expression has not been studied. Expression of ERCC3 was quantified by real-time reverse transcription polymerase chain reaction (RT-PCR) using LightCycler in 43 primary esophageal squamous cell carcinomas (ESCCs) and their paired normal esophageal mucosa. We examined the correlation between the ERCC3 expression and the clinicopathological factors and prognosis of ESCC patients. ERCC3 expression level was significantly correlated with the pathologic stage, tumor size and local invasiveness (t-factor) in esophageal cancer tissues. Reduced expression of ERCC3 was accompanied with tumor progression (p=0.0049) and higher pathologic stage (p=0.020). Moreover, ESCC patients with low ERCC3 mRNA expression had significantly shorter post-operative survival time than those with high expression (p=0.0003). In esophageal cancer, reduced expression of ERCC3 was correlated with local tumor progression and poor prognosis after operation.
Authors:
Yukio Terashita; Hideyuki Ishiguro; Nobuhiro Haruki; Hironori Sugiura; Tadashi Tanaka; Masahiro Kimura; Noriyuki Shinoda; Yoshiyuki Kuwabara; Yoshitaka Fujii
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Oncology reports     Volume:  12     ISSN:  1021-335X     ISO Abbreviation:  Oncol. Rep.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-09-17     Completed Date:  2005-03-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9422756     Medline TA:  Oncol Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  827-31     Citation Subset:  IM    
Affiliation:
Second Department of Surgery, Nagoya City University Medical School, Nagoya 467-8601, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Carcinoma, Squamous Cell / genetics*,  metabolism,  pathology
DNA Helicases / genetics*,  metabolism
DNA Repair
DNA-Binding Proteins
Disease Progression
Esophageal Neoplasms / genetics*,  metabolism,  pathology
Esophagus / metabolism
Female
Humans
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Invasiveness / pathology
Prognosis
RNA, Messenger
RNA, Neoplasm
Reverse Transcriptase Polymerase Chain Reaction
Survival Rate
Tumor Markers, Biological
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/RNA, Messenger; 0/RNA, Neoplasm; 0/Tumor Markers, Biological; 146045-44-5/XPBC-ERCC-3 protein; EC 3.6.1.-/DNA Helicases

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