Document Detail

Excimer laser for various degrees of myopia. A new model estimating the immediate response, the regression, the final response and the time relationship.
MedLine Citation:
PMID:  9591939     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To demonstrate a unified model for various degrees of myopia, characterizing the response-time relationship and its influence of topical corticosteroids. METHODS: 84 eyes were treated with excimer laser for myopia (median -7.1 D). 50 eyes received topical NSAID for 4 days (group 1), and 34 eyes (group 2) were further treated postoperatively with bandage lens and topical corticosteroids for three months. The response-time relationship was expressed as P(t)=a+b*exp(k*t), where P(t) is the response expressed as the percent change in dioptric power to the postoperative time t, a is the final percent response, b is the total percent regression and k the time constant. a+b express the percent immediate response and T1/2=0.69/k denote the time within which half of the total regression has occurred. RESULTS: The immediate and final responses were significantly larger in group 2 (128.9% and 70.5%) compared with group 1 (110.5% and 59.8%). T1/2 was significantly longer in group 2 (2.1 month) compared with group 1 (0.8 month) CONCLUSION: Use of bandage lens together with steroids significantly influences the response-time relationship after excimer laser treatment for myopia.
C Edmund
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Acta ophthalmologica Scandinavica     Volume:  76     ISSN:  1395-3907     ISO Abbreviation:  Acta Ophthalmol Scand     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-06-19     Completed Date:  1998-06-19     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  9507578     Medline TA:  Acta Ophthalmol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  131-7     Citation Subset:  IM    
Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Denmark.
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MeSH Terms
Administration, Topical
Adrenal Cortex Hormones / therapeutic use
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage,  therapeutic use
Cornea / physiopathology
Laser Therapy*
Middle Aged
Myopia / drug therapy,  physiopathology,  surgery*
Occlusive Dressings
Postoperative Period
Refraction, Ocular / physiology
Time Factors
Treatment Outcome
Visual Acuity / physiology
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Anti-Inflammatory Agents, Non-Steroidal

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