Document Detail


Exchange transfusion with synthetic oxygen-carrying plasma protein "albumin-heme" into an acute anemia rat model after seventy-percent hemodilution.
MedLine Citation:
PMID:  15514927     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recombinant human serum albumin (rHSA) incorporating the synthetic heme "albumin-heme" is an oxygen-carrying plasma protein that has the potential to be a red blood cell substitute. The physiological responses to a 30% exchange transfusion with two types of albumin-heme (rHSA-FecycP, rHSA-FepivP) solutions after 70% isovolemic hemodilution with 5 g/dL rHSA were investigated using anesthetized rats. The circulation parameters, blood parameters, renal cortical oxygen pressure (pO2), and muscle tissue pO2 were carefully monitored for 60 min after the injection. The declined mean arterial pressure and the mixed venous partial pO2 significantly recovered to 70.8 and 91.9% of the basal values by intravenous infusion of albumin-hemes, respectively. The lowered renal cortical pO2 also increased, indicating oxygen transport by this synthetic hemoprotein. The administration of albumin-heme into the acute anemia rat model after hemorrhage improved the circulatory volume and resuscitated the shock state. Both rHSA-FecycP and rHSA-FepivP transported oxygen through the body.
Authors:
Teruyuki Komatsu; Hisashi Yamamoto; Yubin Huang; Hirohisa Horinouchi; Koichi Kobayashi; Eishun Tsuchida
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomedical materials research. Part A     Volume:  71     ISSN:  1549-3296     ISO Abbreviation:  -     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-19     Completed Date:  2005-05-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101234237     Medline TA:  J Biomed Mater Res A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  644-51     Citation Subset:  IM    
Affiliation:
Advanced Research Institute for Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan.
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MeSH Terms
Descriptor/Qualifier:
Anemia / drug therapy*
Animals
Blood Gas Analysis
Blood Proteins / therapeutic use*
Blood Substitutes / therapeutic use*
Exchange Transfusion, Whole Blood / methods*
Heme / pharmacology*
Hemodilution*
Hemodynamics / drug effects
Kidney Cortex / drug effects,  metabolism
Male
Muscle, Skeletal / drug effects,  metabolism
Oxygen / blood
Rats
Rats, Wistar
Respiratory Mechanics / drug effects
Serum Albumin / therapeutic use*
Shock, Hemorrhagic / drug therapy,  physiopathology
Survival Analysis
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Blood Substitutes; 0/Serum Albumin; 14875-96-8/Heme; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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