| Exchange transfusion with Fluosol 43: in vivo assessment of cerebral cytochrome c oxidase redox state. | |
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MedLine Citation:
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PMID: 6290684 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rats were serially exchange transfused to hematocrits less than 2% (50-cc exchange) with either Krebs-Henseleit-albumin (KHA) solution or Fluosol-43 (F-43). Reflectance spectrophotometry was employed to monitor cerebral cytochrome c oxidase redox states. Determination of mean arterial pressure (MAP), arterial and venous oxygen content difference (A-VO2), and cerebral cortical ATP and lactate concentrations were also made. As hemodilution progressed, neither solution provided normal quantities of oxygen as evaluated by the cytochrome c oxidase redox state and a decrease in A-VO2 difference, although F-43 was significantly (p less than 0.01) better than KHA in terms of cytochrome c oxidase redox state as well as maintenance of MAP. There was no significant difference between the two test solutions in terms of cortical ATP and lactate. |
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Authors:
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A L Sylvia; H J Proctor; M M Goldsmith; F F Jöbsis |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of trauma Volume: 22 ISSN: 0022-5282 ISO Abbreviation: J Trauma Publication Date: 1982 Oct |
Date Detail:
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Created Date: 1982-12-18 Completed Date: 1982-12-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376373 Medline TA: J Trauma Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 815-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Animals Blood Pressure Blood Substitutes / therapeutic use* Brain / metabolism* Cytochrome c Group / metabolism* Electron Transport Complex IV / metabolism* Exchange Transfusion, Whole Blood* Fluorocarbons / therapeutic use* Lactates / metabolism Male Oxidation-Reduction Oxygen / blood Rats Rats, Inbred Strains |
| Grant Support | |
ID/Acronym/Agency:
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AG-00517/AG/NIA NIH HHS; NS 06233/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Substitutes; 0/Cytochrome c Group; 0/Fluorocarbons; 0/Lactates; 311-89-7/perfluorotributylamine; 56-65-5/Adenosine Triphosphate; 7782-44-7/Oxygen; EC 1.9.3.1/Electron Transport Complex IV |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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