Document Detail

Exchange transfusion with Fluosol 43: in vivo assessment of cerebral cytochrome c oxidase redox state.
MedLine Citation:
PMID:  6290684     Owner:  NLM     Status:  MEDLINE    
Rats were serially exchange transfused to hematocrits less than 2% (50-cc exchange) with either Krebs-Henseleit-albumin (KHA) solution or Fluosol-43 (F-43). Reflectance spectrophotometry was employed to monitor cerebral cytochrome c oxidase redox states. Determination of mean arterial pressure (MAP), arterial and venous oxygen content difference (A-VO2), and cerebral cortical ATP and lactate concentrations were also made. As hemodilution progressed, neither solution provided normal quantities of oxygen as evaluated by the cytochrome c oxidase redox state and a decrease in A-VO2 difference, although F-43 was significantly (p less than 0.01) better than KHA in terms of cytochrome c oxidase redox state as well as maintenance of MAP. There was no significant difference between the two test solutions in terms of cortical ATP and lactate.
A L Sylvia; H J Proctor; M M Goldsmith; F F Jöbsis
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of trauma     Volume:  22     ISSN:  0022-5282     ISO Abbreviation:  J Trauma     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1982-12-18     Completed Date:  1982-12-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376373     Medline TA:  J Trauma     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  815-9     Citation Subset:  AIM; IM    
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MeSH Terms
Adenosine Triphosphate / metabolism
Blood Pressure
Blood Substitutes / therapeutic use*
Brain / metabolism*
Cytochrome c Group / metabolism*
Electron Transport Complex IV / metabolism*
Exchange Transfusion, Whole Blood*
Fluorocarbons / therapeutic use*
Lactates / metabolism
Oxygen / blood
Rats, Inbred Strains
Grant Support
Reg. No./Substance:
0/Blood Substitutes; 0/Cytochrome c Group; 0/Fluorocarbons; 0/Lactates; 311-89-7/perfluorotributylamine; 56-65-5/Adenosine Triphosphate; 7782-44-7/Oxygen; EC Transport Complex IV

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