Document Detail

Exchange transfusion as an adjunct to the treatment of severe falciparum malaria.
MedLine Citation:
PMID:  9537279     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the efficacy of exchange transfusion as the adjunct to quinine treatment (21 patients) with quinine therapy alone (29 patients). METHOD: A retrospective study of 50 patients with severe falciparum malaria was conducted at Chumphorn Hospital, Southern Thailand. RESULTS: Clinical characteristics in both treatment groups were not significantly different although in the exchange transfusion group, the admission geometric mean parasitaemia (18 (5%), and the proportion of patients with more than 10% parasitaemia was higher (76%, P = 0.03) than in the group who received quinine alone (10 +/- 4%; 38%, P = 0.1). The mortality rate of patients who received exchange transfusion was 48%; that of the remainder, 69%. (P = 0.3). ARDS (P = 0.01) and oliguric renal failure (P = 0.04) were significant risk factors for death in these patients. CONCLUSION: Exchange transfusion was safe and well tolerated. Results of our study revealed a 20% reduction in mortality when exchange transfusion was used as an adjunct to quinine treatment. It should therefore be considered in patients with severe falciparum malaria when possible.
S Hoontrakoon; Y Suputtamongkol
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Tropical medicine & international health : TM & IH     Volume:  3     ISSN:  1360-2276     ISO Abbreviation:  Trop. Med. Int. Health     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-04-16     Completed Date:  1998-04-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9610576     Medline TA:  Trop Med Int Health     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  156-61     Citation Subset:  IM    
Department of Medicine, Chumphorn Hospital, Thailand.
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MeSH Terms
Antimalarials / therapeutic use*
Combined Modality Therapy
Exchange Transfusion, Whole Blood*
Kidney Failure, Acute / parasitology
Malaria, Falciparum / complications,  parasitology,  therapy*
Quinine / therapeutic use*
Respiratory Distress Syndrome, Adult / parasitology
Retrospective Studies
Risk Factors
Severity of Illness Index
Survival Analysis
Treatment Outcome
Reg. No./Substance:
0/Antimalarials; 130-95-0/Quinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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