| Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein. | |
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MedLine Citation:
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PMID: 12150997 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Defining the molecular mechanisms that integrate diverse signaling pathways at the level of gene transcription remains a central issue in biology. Here, we demonstrate that interleukin-1beta (IL-1beta) causes nuclear export of a specific N-CoR corepressor complex, resulting in derepression of a specific subset of NF-kappaB-regulated genes, exemplified by the tetraspanin KAI1 that regulates membrane receptor function. Nuclear export of the N-CoR/TAB2/HDAC3 complex by IL-1beta is temporally linked to selective recruitment of a Tip60 coactivator complex. Surprisingly, KAI1 is also directly activated by a ternary complex, dependent on the acetyltransferase activity of Tip60, consisting of the presenilin-dependent C-terminal cleavage product of the amyloid beta precursor protein (APP), Fe65, and Tip60, identifying a specific in vivo gene target of an APP-dependent transcription complex in the brain. |
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Authors:
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Sung Hee Baek; Kenneth A Ohgi; David W Rose; Edward H Koo; Christopher K Glass; Michael G Rosenfeld |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cell Volume: 110 ISSN: 0092-8674 ISO Abbreviation: Cell Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-08-01 Completed Date: 2002-08-29 Revised Date: 2011-11-02 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: United States |
Other Details:
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Languages: eng Pagination: 55-67 Citation Subset: IM |
Affiliation:
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Howard Hughes Medical Institute, Department of Molecular Medicine, La Jolla, CA 92093, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetyltransferases
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genetics,
physiology Active Transport, Cell Nucleus Adaptor Proteins, Signal Transducing* Amino Acid Sequence Amyloid beta-Protein Precursor / genetics, metabolism, physiology* Animals Antigens, CD* Carrier Proteins / physiology Cells, Cultured Cercopithecus aethiops Histone Acetyltransferases Humans Interleukin-1 / physiology* Kangai-1 Protein MAP Kinase Kinase Kinase 1* Membrane Glycoproteins / genetics*, physiology Molecular Sequence Data NF-kappa B / metabolism, physiology* Nerve Tissue Proteins / genetics, physiology Nuclear Proteins / genetics, physiology* Nuclear Receptor Co-Repressor 1 Promoter Regions, Genetic Protein-Serine-Threonine Kinases / physiology Proto-Oncogene Proteins* RNA, Messenger / biosynthesis Repressor Proteins / physiology* Signal Transduction Up-Regulation |
| Chemical | |
Reg. No./Substance:
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0/APBB1 protein, human; 0/Adaptor Proteins, Signal Transducing; 0/Amyloid beta-Protein Precursor; 0/Antigens, CD; 0/CD82 protein, human; 0/Carrier Proteins; 0/Interleukin-1; 0/Kangai-1 Protein; 0/Membrane Glycoproteins; 0/NCOR1 protein, human; 0/NF-kappa B; 0/Nerve Tissue Proteins; 0/Nuclear Proteins; 0/Nuclear Receptor Co-Repressor 1; 0/Proto-Oncogene Proteins; 0/RNA, Messenger; 0/Repressor Proteins; 0/TAB2 protein, human; EC 2.3.1.-/Acetyltransferases; EC 2.3.1.-/KAT5 protein, human; EC 2.3.1.48/Histone Acetyltransferases; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.25/MAP Kinase Kinase Kinase 1; EC 2.7.11.25/MAP3K1 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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