Document Detail


Excessive weight gain as a possible predictor of necrotizing enterocolitis in premature infants.
MedLine Citation:
PMID:  17274351     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Necrotizing enterocolitis is a common progressive gastrointestinal disease affecting more than 5% of very low birth weight infants and associated with a high mortality rate. OBJECTIVES: To determine whether excessive weight gain in preterm infants is an early sign of NEC. METHODS: Seventeen preterm infants with perforated NEC were identified and matched with 17 control subjects for birth weight and gestational age. The postnatal age (days) at diagnosis of NEC was identified, and weight changes as well as clinical and laboratory data were recorded and compared for 7 days prior through 7 days post-diagnosis. RESULTS: A significant difference in weight gain was noticed between D-1 and D 0. The NEC and control groups gained 5.1% and 1.2%, respectively (P = 0.002). None of the sick infants lost weight on days -1 to D 0. CONCLUSIONS: Excessive weight gain was observed in premature infants who subsequently developed NEC. Daily evaluation of weight changes should be considered part of a strategy for early identification of infants at risk for developing NEC. Future studies are needed to confirm this finding in a prospective manner and to investigate its pathogenesis.
Authors:
Iris Morag; Michael Goldman; Jacob Kuint; Eli Heyman
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Israel Medical Association journal : IMAJ     Volume:  9     ISSN:  1565-1088     ISO Abbreviation:  Isr. Med. Assoc. J.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-02-05     Completed Date:  2007-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100930740     Medline TA:  Isr Med Assoc J     Country:  Israel    
Other Details:
Languages:  eng     Pagination:  24-7     Citation Subset:  IM    
Affiliation:
Neonatal Intensive Care Unit, Assaf Harofeh Medical Center, Zerifin, Israel.
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MeSH Terms
Descriptor/Qualifier:
Birth Weight
Case-Control Studies
Enterocolitis, Necrotizing / diagnosis*,  physiopathology
Female
Gestational Age
Humans
Infant, Newborn
Infant, Premature*
Male
Retrospective Studies
Weight Gain*

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