Document Detail

Excessive plasma K+ increase after ischemic exercise in myotonic muscular dystrophy.
MedLine Citation:
PMID:  2325699     Owner:  NLM     Status:  MEDLINE    
Changes in plasma electrolyte levels upon ischemic forearm exercise were studied in myotonic muscular dystrophy (MyD) patients, disease control groups, and healthy volunteers. Significant differences were observed in the pH and the concentrations of creatine kinase and Na+ before exercise between healthy volunteers and MyD patients. In comparison with healthy volunteers a lower pH and higher concentrations of both CK and Na+ were found in MyD patients. The concentrations of K+, inorganic phosphate, lactate, and ammonia increase upon exercise in all groups. The mean increase in plasma K+ for healthy volunteers amounted to 0.8 mM (= 23%). In MyD patients a significantly higher increase in plasma K+ was found [mean 2.2 mM (= 65%)]. No abnormal release of K+ from muscular tissue was found in the disease control groups. Data on the postexercise increase in the concentration of other muscular constituents such as creatine kinase, inorganic phosphate, or creatine exclude the possibility of a generally increased membrane permeability in MyD. The abnormally high increase of plasma K+ upon muscular exercise seems to be specific for MyD and may be related to the biochemical defect in this disease.
R A Wevers; M G Joosten; J B van de Biezenbos; G M Theewes; J H Veerkamp
Related Documents :
14767419 - Effect of sprint duration (6 s or 30 s) on plasma glucose regulation in untrained male ...
23756389 - The impact of physical activity and nutrition on inflammatory bowel disease: the potent...
24725369 - Benefits of whole body vibration training in patients hospitalised for copd exacerbatio...
11293389 - The effects of exercise on the pharmacokinetics of drugs.
1425629 - Plasma volume, osmolarity, total protein and electrolytes during treadmill running and ...
23532149 - Effect of exercise modality and intensity on postexercise interleukin-6 and hepcidin le...
24371829 - Interval and continuous exercise training produce similar increases in skeletal muscle ...
20956859 - Inflammatory cytokines and metabolic risk factors during growth and maturation: influen...
15463869 - Treatment of urinary incontinence in cystic fibrosis.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Muscle & nerve     Volume:  13     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-05-16     Completed Date:  1990-05-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  27-32     Citation Subset:  IM; S    
Institute of Neurology, University Hospital Nijmegen, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Exercise / physiology*
Lactates / blood
Muscles / physiopathology
Muscular Dystrophies / blood,  physiopathology*
Potassium / blood*
Reg. No./Substance:
0/Lactates; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Paramyotonia congenita or hyperkalemic periodic paralysis? Clinical and electrophysiological feature...
Next Document:  Calf enlargement in hereditary motor and sensory neuropathy.