Document Detail

Excessive gas exchange impairment during exercise in a subject with a history of bronchopulmonary dysplasia and high altitude pulmonary edema.
MedLine Citation:
PMID:  17394419     Owner:  NLM     Status:  MEDLINE    
A 27-year-old male subject (V(O2 max)), 92% predicted) with a history of bronchopulmonary dysplasia (BPD) and a clinically documented case of high altitude pulmonary edema (HAPE) was examined at rest and during exercise. Pulmonary function testing revealed a normal forced vital capacity (FVC, 98.1% predicted) and diffusion capacity for carbon monoxide (D(L(CO)), 91.2% predicted), but significant airway obstruction at rest [forced expiratory volume in 1 sec (FEV(1)), 66.5% predicted; forced expiratory flow at 50% of vital capacity (FEF(50)), 34.3% predicted; and FEV(1) /FVC 56.5%] that was not reversible with an inhaled bronchodilator. Gas exchange worsened from rest to exercise, with the alveolar to arterial P(O2) difference (AaD(O2)) increasing from 0 at rest to 41 mmHg at maximal normoxic exercise (VO(2) = 41.4 mL/kg/min) and from 11 to 31 mmHg at maximal hypoxic exercise (VO(2) = 21.9 mL/kg/min). Arterial P(O2) decreased to 67.8 and 29.9 mmHg at maximal normoxic and hypoxic exercise, respectively. These data indicate that our subject with a history of BPD is prone to a greater degree of exercise-induced arterial hypoxemia for a given VO(2) and F(I(O2)) than healthy age-matched controls, which may increase the subject's susceptibility to high altitude illness.
Andrew T Lovering; Lee M Romer; Hans C Haverkamp; John S Hokanson; Marlowe W Eldridge
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  High altitude medicine & biology     Volume:  8     ISSN:  1527-0297     ISO Abbreviation:  High Alt. Med. Biol.     Publication Date:  2007  
Date Detail:
Created Date:  2007-03-30     Completed Date:  2007-05-17     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  100901183     Medline TA:  High Alt Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  62-7     Citation Subset:  IM; S    
University of Wisconsin School of Medicine and Public Health, Department of Population Health Sciences, John Rankin Laboratory of Pulmonary Medicine, Madison, Wisconsin 53706-1532, USA.
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MeSH Terms
Altitude Sickness / complications,  physiopathology*
Bronchopulmonary Dysplasia / physiopathology*
Exercise Test / methods
Exercise Tolerance
Forced Expiratory Flow Rates
Forced Expiratory Volume
Infant, Newborn
Oxygen Consumption
Pulmonary Edema / complications,  physiopathology*
Pulmonary Gas Exchange*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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