| Excessive gas exchange impairment during exercise in a subject with a history of bronchopulmonary dysplasia and high altitude pulmonary edema. | |
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MedLine Citation:
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PMID: 17394419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 27-year-old male subject (V(O2 max)), 92% predicted) with a history of bronchopulmonary dysplasia (BPD) and a clinically documented case of high altitude pulmonary edema (HAPE) was examined at rest and during exercise. Pulmonary function testing revealed a normal forced vital capacity (FVC, 98.1% predicted) and diffusion capacity for carbon monoxide (D(L(CO)), 91.2% predicted), but significant airway obstruction at rest [forced expiratory volume in 1 sec (FEV(1)), 66.5% predicted; forced expiratory flow at 50% of vital capacity (FEF(50)), 34.3% predicted; and FEV(1) /FVC 56.5%] that was not reversible with an inhaled bronchodilator. Gas exchange worsened from rest to exercise, with the alveolar to arterial P(O2) difference (AaD(O2)) increasing from 0 at rest to 41 mmHg at maximal normoxic exercise (VO(2) = 41.4 mL/kg/min) and from 11 to 31 mmHg at maximal hypoxic exercise (VO(2) = 21.9 mL/kg/min). Arterial P(O2) decreased to 67.8 and 29.9 mmHg at maximal normoxic and hypoxic exercise, respectively. These data indicate that our subject with a history of BPD is prone to a greater degree of exercise-induced arterial hypoxemia for a given VO(2) and F(I(O2)) than healthy age-matched controls, which may increase the subject's susceptibility to high altitude illness. |
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Authors:
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Andrew T Lovering; Lee M Romer; Hans C Haverkamp; John S Hokanson; Marlowe W Eldridge |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: High altitude medicine & biology Volume: 8 ISSN: 1527-0297 ISO Abbreviation: High Alt. Med. Biol. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-03-30 Completed Date: 2007-05-17 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 100901183 Medline TA: High Alt Med Biol Country: United States |
Other Details:
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Languages: eng Pagination: 62-7 Citation Subset: IM; S |
Affiliation:
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University of Wisconsin School of Medicine and Public Health, Department of Population Health Sciences, John Rankin Laboratory of Pulmonary Medicine, Madison, Wisconsin 53706-1532, USA. atlovering@wisc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Altitude Sickness / complications, physiopathology* Bronchopulmonary Dysplasia / physiopathology* Exercise* Exercise Test / methods Exercise Tolerance Forced Expiratory Flow Rates Forced Expiratory Volume Humans Infant, Newborn Male Oxygen Consumption Pulmonary Edema / complications, physiopathology* Pulmonary Gas Exchange* |
| Grant Support | |
ID/Acronym/Agency:
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HL-15469/HL/NHLBI NIH HHS; T32 HL07654/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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