| Excessive fat restriction might promote the recurrence of colorectal tumors. | |
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MedLine Citation:
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PMID: 20099189 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The incidence of colorectal cancer is rapidly increasing in Japan. This trend has been suggested to be caused by an increasing fat intake as a result of the Westernized diet among Japanese. We investigated whether dietary instruction optimizing the fat energy ratio suppresses the recurrence of colorectal tumors. The subjects, 373 men and women, were the participants in a randomized clinical trial of colorectal cancer prophylaxis. At entry, each participant completed a 3-consecutive-day food record on which dietary instruction was given to restrict fat energy ratio to 18-22%. Data obtained before and after the intervention were examined by cohort analysis. The primary endpoint was the presence or absence of colorectal tumor(s) at colonoscopy after 4 yr. Unexpectedly, the recurrence of tumor increased as the subjects reduced their fat intake. The lowest tumor recurrence among the men was observed in the group with 23.8-26.4% fat energy ratio after the intervention. Furthermore, in men, the risk of tumors decreased significantly as the intake of linoleic acids per body weight increased. For women, similar trends were observed. These results suggest that extreme fat restriction is highly likely to promote the recurrence of colorectal tumors, which may be partly attributable to linoleic acid deficiency. |
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Authors:
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Tomiyo Nakamura; Hideki Ishikawa; Ikuko Takeyama; Atsuko Kawano; Shingo Ishiguro; Toru Otani; Toyoko Okuda; Yoshitaka Murakami; Toshiyuki Sakai; Nariaki Matsuura |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nutrition and cancer Volume: 62 ISSN: 1532-7914 ISO Abbreviation: Nutr Cancer Publication Date: 2010 |
Date Detail:
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Created Date: 2010-01-25 Completed Date: 2010-03-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7905040 Medline TA: Nutr Cancer Country: England |
Other Details:
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Languages: eng Pagination: 154-63 Citation Subset: IM |
Affiliation:
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Osaka University Graduate School of Medicine and Health Science, Osaka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Colonoscopy Colorectal Neoplasms / epidemiology*, prevention & control Diet Records Diet, Fat-Restricted / adverse effects* Dietary Fiber Energy Intake Female Humans Lactobacillus casei Linoleic Acid / administration & dosage Male Middle Aged Neoplasm Recurrence, Local / epidemiology*, etiology, prevention & control Odds Ratio Probiotics Sex Factors |
| Chemical | |
Reg. No./Substance:
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2197-37-7/Linoleic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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