Document Detail

Excessive daytime sleepiness and the pathophysiology of narcolepsy-cataplexy: a laboratory perspective.
MedLine Citation:
PMID:  3704444     Owner:  NLM     Status:  MEDLINE    
The main disabling symptom of narcolepsy-cataplexy is shown to be the unrelenting excessive daytime sleepiness (EDS) based upon controlled studies of socioeconomic effects and the poor response to treatment. Objective performance deficits mainly involve tests of ability to sustain performance on repetitive boring tasks and are reversible by improved alertness. Physiologically, EDS is seen to represent relatively slow waxing and waning of alertness rather than punctate microsleeps. Evidence is provided for complex cerebral evoked potentials (P300, contingent negative variation) being very sensitive EDS measures comparable to the multiple sleep latency test (MSLT). EDS appears to have qualitatively somewhat different forms mainly reflecting pressure for REM sleep (REM sleepiness) or pressure for NREM sleep (NREM sleepiness), which have different effects on cerebral evoked potentials as well as subjective and objective (MSLT) differences. It is argued that in pathophysiological terms narcolepsy may best be considered a disease of state boundary control.
R Broughton; V Valley; M Aguirre; J Roberts; W Suwalski; W Dunham
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Sleep     Volume:  9     ISSN:  0161-8105     ISO Abbreviation:  Sleep     Publication Date:  1986  
Date Detail:
Created Date:  1986-06-12     Completed Date:  1986-06-12     Revised Date:  2009-01-29    
Medline Journal Info:
Nlm Unique ID:  7809084     Medline TA:  Sleep     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  205-15     Citation Subset:  IM    
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MeSH Terms
Cataplexy / physiopathology*
Evoked Potentials
Monitoring, Physiologic
Narcolepsy / diagnosis,  physiopathology*
Sleep / physiology*
Sleep Stages / physiology
Socioeconomic Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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