Document Detail

Excessive blood pressure elevation upon awakening involves an exaggerated cardiac response to slight physical activity: a possible mechanism underlying the risk of 'morning surge'.
MedLine Citation:
PMID:  22968107     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: An exaggerated elevation in blood pressure around waking potentially increases the risk of cardiovascular events, even in individuals with normal blood pressure at other-fold of day. The impact of such a transient blood pressure elevation is disproportionate to its short duration, and the reason has not been elucidated. We hypothesize that individuals with such a blood pressure abnormality receive a cardiovascular overload, even from slight physical activities that are frequently undertaken in daily life.
METHODS: A total of 16 patients with essential hypertension (52±15 years) staying at hospital for lifestyle education participated in this study. Morning blood pressure elevation was assessed with 24 h ambulatory blood pressure monitoring. Cardiovascular responses to unloaded pedaling, including blood pressure changes, were assessed in a limited maximum exercise test using an electronically braked bicycle ergometer.
RESULTS: Changes in the systolic blood pressure caused by unloaded pedaling correlated positively with the elevation in systolic blood pressure around waking (r=0.52, P=0.05). Moreover, waking elevation of the systolic blood pressure correlated with changes in all of the following cardiovascular variables during unloaded pedaling: heart rate (r=0.69, P=0.003), oxygen consumption (r=0.73, P=0.001), oxygen pulse (r=0.62, P=0.001), and rate pressure product (r=0.64, P=0.008), respectively.
CONCLUSION: These observations indicate that individuals with prominent blood pressure elevation upon awakening also experience cardiovascular overload from slight physical activities.
Yoshimasa Wakamatsu; Yutaka Takeda; Satoru Tanaka; Koji Yamamoto; Sumiyo Yamashita; Tomonori Sugiura; Yasuaki Dohi; Genjiro Kimura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blood pressure monitoring     Volume:  17     ISSN:  1473-5725     ISO Abbreviation:  Blood Press Monit     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9606438     Medline TA:  Blood Press Monit     Country:  England    
Other Details:
Languages:  eng     Pagination:  198-203     Citation Subset:  IM    
Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Science, Nagoya, Aichi, Japan.
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