| Excessive activation of the complement system in atypical hemolytic uremic syndrome: is it ready for prime time? | |
| | |
MedLine Citation:
|
PMID: 20118898 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Complement factor I (CFI) mutations are implicated in the pathogenesis of atypical hemolytic uremic syndrome (aHUS). Nevertheless, there is evidence that CFI deficiency is a weak effector of aHUS. Bienaime et al. report that homozygous deletion of CFHR-1 in the RCA gene cluster of chromosome 1q is a major risk factor for poor outcome for patients with CFI mutations. The basic and clinical implications of the findings are further elaborated here. |
| | |
Authors:
|
Han-Mou Tsai |
Related Documents
:
|
16225828 - Mecp2 dysfunction in humans and mice. 19562618 - Jak2 v617f mutation is associated with 5q- syndrome in chinese. 12400058 - Distinct craniofacial-skeletal-dermatological dysplasia in a patient with w290c mutatio... 9207788 - Alagille syndrome is caused by mutations in human jagged1, which encodes a ligand for n... 617578 - Tonic pupils with acute ophthalmoplegic polyneuritis. 11018828 - Cerebellar vermis hypoplasia - non progressive congenital ataxia: clinical and radiolog... |
Publication Detail:
|
Type: Comment; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Kidney international Volume: 77 ISSN: 1523-1755 ISO Abbreviation: Kidney Int. Publication Date: 2010 Feb |
Date Detail:
|
Created Date: 2010-02-01 Completed Date: 2010-06-04 Revised Date: 2011-09-26 |
Medline Journal Info:
|
Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: United States |
Other Details:
|
Languages: eng Pagination: 267-9 Citation Subset: IM |
Affiliation:
|
Division of Hematology/Oncology, Pennsylvania State University, Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033, USA. htsai@hmc.psu.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Complement Activation* Hemolytic-Uremic Syndrome / immunology* Humans |
| Grant Support | |
ID/Acronym/Agency:
|
R01 HL062136-10/HL/NHLBI NIH HHS; R01HL62136/HL/NHLBI NIH HHS |
| Comments/Corrections | |
Comment On:
|
Kidney Int. 2010 Feb;77(4):339-49
[PMID:
20016463
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Determining the reactivity and titre of serum using a haemagglutination assay.
Next Document: Functional evidence confirmed by histological localization: overlapping expression of erythropoietin...