Excess mortality and morbidity in patients with craniopharyngioma, especially in patients with childhood-onset - a population-based study in Sweden. | |
MedLine Citation:
|
PMID: 25375987 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Context: Craniopharyngiomas in adults have been associated with excess mortality. Objective: The aim of the study was to investigate mortality and morbidity in childhood-onset and adult-onset craniopharyngioma patients. Methods: Craniopharyngioma patients were identified and followed in Swedish national health registries, 1987-2011. The inclusion criteria for the craniopharyngioma diagnosis were internally validated in 28% of the study population against patient records. Settings: Nationwide population-based study. Patients: 307 patients (151 men; 156 women) were identified and included (mean follow-up: 9 years, range 0-25). The inclusion criteria had a positive predictive value of 97% and a sensitivity of 92%. Intervention: None. Main Outcome Measures: Standardized mortality ratios (SMRs) and standardized incidence ratios (SIRs) with 95% confidence intervals were calculated using the Swedish population as reference. Results: During the study 54 patients died compared with the expected number of 14.1, resulting in an SMR of 3.2 (2.2-4.7) for men and 4.9 (3.2-7.2) for women. Childhood-onset (n=106) and adult-onset craniopharyngioma (n=201) had SMRs of 17 (6.3-37) and 3.5 (2.6-4.6), respectively. Patients with hypopituitarism (n=250), diabetes insipidus (n=110), and neither of these (n=54) had SMRs of 4.3 (3.1-5.8), 6.1 (3.5-9.7), and 2.7 (1.4-4.6), respectively. SMR due to cerebrovascular diseases was 5.1 (1.7-12). SIRs were 5.6 (3.8-8.0) for type 2 diabetes mellitus (T2DM), 7.1 (5.0-9.9) for cerebral infarction, 0.7 (0.2-1.7) for myocardial infarction, 2.1 (1.4-3.0) for fracture, and 5.9 (3.4-9.4) for severe infection. The SIR for all malignant tumors was 1.3 (0.8-2.1). Conclusions: This first nationwide population-based study of craniopharyngioma patients demonstrated an excess mortality that was especially marked in patients with childhood-onset disease and among women. Death due to cerebrovascular diseases was increased five-fold. Hypopituitarism and diabetes insipidus were negative prognostic factors for mortality and morbidity. Craniopharyngioma patients suffered from an increased disease burden related to T2DM, cerebral infarction, fracture, and severe infection. |
Authors:
|
Daniel S Olsson; Eva Andersson; Ing-Liss Bryngelsson; Anna G Nilsson; Gudmundur Johannsson |
Related Documents
:
|
9331207 - Central serous chorioretinopathy associated with inhaled or intranasal corticosteroids. 16820327 - The natural history of corticosteroid therapy for ulcerative colitis in children. 22522147 - Enhancing informed consent best practices: gaining patient, family and provider perspec... 25442867 - Pseudomonas aeruginosa infective endocarditis in patients who do not use intravenous dr... 20386997 - The return of bedside rounds: an educational intervention. 12381507 - Staging of patients with ankylosing spondylitis: a preliminary proposal. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2014-11-6 |
Journal Detail:
|
Title: The Journal of clinical endocrinology and metabolism Volume: - ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2014 Nov |
Date Detail:
|
Created Date: 2014-11-6 Completed Date: - Revised Date: 2014-11-7 |
Medline Journal Info:
|
Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: - |
Other Details:
|
Languages: ENG Pagination: jc20143525 Citation Subset: - |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
MeSH Terms | |
Descriptor/Qualifier:
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Apparent Heterozygosity of a CYP24A1 Mutation Manifesting as Nephrolithiasis - Assessment in a Novel...
Next Document: Origin of the Phase Transition in Lithiated Molybdenum Disulfide.