Document Detail

Excess mortality, hospital stay, and cost due to candidemia: a case-control study using data from population-based candidemia surveillance.
MedLine Citation:
PMID:  16018429     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the mortality, hospital stay, and total hospital charges and cost of hospitalization attributable to candidemia by comparing patients with candidemia with control-patients who have otherwise similar illnesses. Prior studies lack broad patient and hospital representation or cost-related information that accurately reflects current medical practices. DESIGN: Our case-control study included case-patients with candidemia and their cost-related data, ascertained from laboratory-based candidemia surveillance conducted among all residents of Connecticut and Baltimore and Baltimore County, Maryland, during 1998 to 2000. Control-patients were matched on age, hospital type, admission year, discharge diagnoses, and duration of hospitalization prior to candidemia onset. RESULTS: We identified 214 and 529 sets of matched case-patients and control-patients from the two locations, respectively. Mortality attributable to candidemia ranged between 19% and 24%. On multivariable analysis, candidemia was associated with mortality (OR, 5.3 for Connecticut and 8.5 for Baltimore and Baltimore County; P < .05), whereas receiving adequate treatment was protective (OR, 0.5 and 0.4 for the two locations, respectively; P < .05). Candidemia itself did not increase the total hospital charges and cost of hospitalization; when treatment status was accounted for, having received adequate treatment for candidemia significantly increased the total hospital charges and cost of hospitalization ($6,000 to $29,000 and $3,000 to $22,000, respectively) and the length of stay (3 to 13 days). CONCLUSION: Our findings underscore the burden of candidemia, particularly regarding the risk of death, length of hospitalization, and cost associated with treatment.
Juliette Morgan; Martin I Meltzer; Brian D Plikaytis; Andre N Sofair; Sharon Huie-White; Steven Wilcox; Lee H Harrison; Eric C Seaberg; Rana A Hajjeh; Steven M Teutsch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America     Volume:  26     ISSN:  0899-823X     ISO Abbreviation:  Infect Control Hosp Epidemiol     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-07-15     Completed Date:  2005-12-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8804099     Medline TA:  Infect Control Hosp Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  540-7     Citation Subset:  IM; N    
Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
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MeSH Terms
Age Distribution
Baltimore / epidemiology
Candidiasis* / economics,  mortality
Case-Control Studies
Child, Preschool
Connecticut / epidemiology
Cost of Illness
Cross Infection* / economics,  mortality
Fungemia* / economics,  mortality
Hospital Charges / statistics & numerical data*
Hospital Costs / statistics & numerical data*
Hospital Mortality*
Length of Stay / economics*
Linear Models
Middle Aged
Multivariate Analysis
Population Surveillance
Erratum In:
Infect Control Hosp Epidemiol. 2005 Aug;26(8):675

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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