Document Detail


Excess mortality associated with influenza A and B virus in Hong Kong, 1998-2009.
MedLine Citation:
PMID:  23045622     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Although deaths associated with laboratory-confirmed influenza virus infections are rare, the excess mortality burden of influenza estimated from statistical models may more reliably quantify the impact of influenza in a population.
METHODS: We applied age-specific multiple linear regression models to all-cause and cause-specific mortality rates in Hong Kong from 1998 through 2009. The differences between estimated mortality rates in the presence or absence of recorded influenza activity were used to estimate influenza-associated excess mortality.
RESULTS: The annual influenza-associated all-cause excess mortality rate was 11.1 (95% confidence interval [CI], 7.2-14.6) per 100,000 person-years. We estimated an average of 751 (95% CI, 488-990) excess deaths associated with influenza annually from 1998 through 2009, with 95% of the excess deaths occurring in persons aged ≥65 years. Most of the influenza-associated excess deaths were from respiratory (53%) and cardiovascular (18%) causes. Influenza A(H3N2) epidemics were associated with more excess deaths than influenza A(H1N1) or B during the study period.
CONCLUSIONS: Influenza was associated with a substantial number of excess deaths each year, mainly among the elderly, in Hong Kong in the past decade. The influenza-associated excess mortality rates were generally similar in Hong Kong and the United States.
Authors:
Peng Wu; Edward Goldstein; Lai Ming Ho; Lin Yang; Hiroshi Nishiura; Joseph T Wu; Dennis K M Ip; Shuk-Kwan Chuang; Thomas Tsang; Benjamin J Cowling
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-08
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  206     ISSN:  1537-6613     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-21     Completed Date:  2013-01-25     Revised Date:  2013-12-18    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1862-71     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Child
Child, Preschool
Female
Hong Kong / epidemiology
Humans
Infant
Infant, Newborn
Influenza A virus / isolation & purification,  pathogenicity*
Influenza B virus / isolation & purification,  pathogenicity*
Influenza, Human / epidemiology*,  mortality*,  virology
Male
Middle Aged
Mortality / trends*
United States / epidemiology
Young Adult
Grant Support
ID/Acronym/Agency:
1K01 AI101010-01/AI/NIAID NIH HHS; K01 AI101010/AI/NIAID NIH HHS; U54 GM088558/GM/NIGMS NIH HHS; U54 GM088558/GM/NIGMS NIH HHS
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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