Document Detail


Excess intravascular coagulation complicating low cardiac output.
MedLine Citation:
PMID:  1091659     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In 42 children with congenital heart disease coagulation factor levels were studied serially during the first 20 hours following cardiopulmonary bypass surgery. The acyanotic patients, and also cyanotic patients who survived the operation, showed a progressive improvement in their coagulation profile from initial low postoperative levels. In 12 cyanotic patients who died within 72 hours, however, the coagulation factor levels either remained low, or fell further, until death. Fresh frozen plasma was administered to eight of these patients without apparent benefit. The abnormal coagulation profile correlated significantly with low skin temperature and increased blood loss and was considered to represent excess intravascular coagulation secondary to low cardiac output and poor tissue perfusion.
Authors:
T C Inglis; G R Breeze; J Stuart; L D Abrams; K D Roberts
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  28     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  1975 Jan 
Date Detail:
Created Date:  1975-06-29     Completed Date:  1975-06-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Blood Coagulation Disorders / complications*,  drug therapy,  therapy
Blood Platelets
Blood Transfusion
Cardiopulmonary Bypass*
Child
Child, Preschool
Cyanosis / etiology
Disseminated Intravascular Coagulation / complications
Extracorporeal Circulation*
Factor V / analysis
Factor VIII / analysis
Fibrin / analysis
Fibrinogen / analysis
Heart Defects, Congenital / blood,  complications*,  surgery
Hematocrit
Heparin / blood
Humans
Infant
Microscopy, Phase-Contrast
Plasminogen / analysis
Protamines / therapeutic use
Skin Temperature
Chemical
Reg. No./Substance:
0/Protamines; 9001-24-5/Factor V; 9001-27-8/Factor VIII; 9001-31-4/Fibrin; 9001-32-5/Fibrinogen; 9001-91-6/Plasminogen; 9005-49-6/Heparin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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