| Excess aldosterone under normal salt diet induces cardiac hypertrophy and infiltration via oxidative stress. | |
| | |
MedLine Citation:
|
PMID: 16156509 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Aldosterone is known to play a role in the pathophysiology of some cardiovascular diseases. However, previous studies on aldosterone infusion have been mostly performed in animals receiving sodium loading and uninephrectomy, and thus the cardiac action of aldosterone alone remains to be fully clarified. The present study was undertaken to investigate the direct cardiac action of aldosterone infusion alone in rats not subjected to salt loading and uninephrectomy. Aldosterone (0.75 microg/h) was subcutaneously infused into rats via an osmotic minipump for 14 days. Aldosterone infusion, under a normal salt diet, induced only a slight increase in the blood pressure of normal rats throughout the infusion. However, aldosterone significantly induced cardiac hypertrophy, as shown by echocardiography and measurement of cardiomyocyte cross-sectional area. Furthermore, aldosterone caused not only cardiac interstitial macrophage infiltration but also cardiac focal inflammatory lesions, which were associated with an increase in cardiac monocyte chemoattractant protein-1 (MCP-1) and osteopontin mRNA. The slight elevation of blood pressure by aldosterone infusion was completely prevented by tempol, the superoxide dismutase mimetic. However, tempol failed to suppress cardiac hypertrophy, the formation of inflammatory lesions, and upregulation of cardiac MCP-1 and osteopontin by aldosterone, while N-acetylcysteine could inhibit all of them. Our data provide evidence that aldosterone alone can induce cardiac hypertrophy and severe inflammatory response in the heart, independently of blood pressure, even in the absence of salt loading or nephrectomy. Aldosterone seems to induce cardiac inflammation and gene expression via oxidative stress that is inhibited by N-acetylcysteine but not by tempol. |
| | |
Authors:
|
Kaoru Yoshida; Shokei Kim-Mitsuyama; Ryotaro Wake; Yasuhiro Izumiya; Yasukatsu Izumi; Tokihito Yukimura; Makiko Ueda; Minoru Yoshiyama; Hiroshi Iwao |
Related Documents
:
|
6360879 - Aldosterone-binding globulin-induced hypertension in the rat. a new experimental model. 11936469 - A case of severe hypertension caused by acth-independent macronodular adrenal hyperplasia. 18212439 - Effect of age on hypertension: analysis of over 4,800 referred hypertensive patients. 21145769 - Endotracheal nebulization of n-acetylcysteine increases airway resistance in cats with ... 17172319 - Subglottic secretion viscosity and evacuation efficiency. 2561139 - Brain corticosteroid receptors and regulation of arterial blood pressure. 6992259 - The influence of cimetidine on the acid gastro-oesophageal reflux in duodenal ulcer pat... 1797999 - Home blood pressure monitoring: advantages and limitations. 8633949 - Improved cardiac function after prolonged hypothermic ischemia with the na+/h+ exchange... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Hypertension research : official journal of the Japanese Society of Hypertension Volume: 28 ISSN: 0916-9636 ISO Abbreviation: Hypertens. Res. Publication Date: 2005 May |
Date Detail:
|
Created Date: 2005-09-13 Completed Date: 2005-10-05 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9307690 Medline TA: Hypertens Res Country: Japan |
Other Details:
|
Languages: eng Pagination: 447-55 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, Osaka City University Graduate School of Medical Science, Osaka, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetylcysteine
/
pharmacology Aldosterone / blood, pharmacology Animals Blood Pressure / drug effects Cardiomegaly / etiology*, metabolism*, ultrasonography Chemokine CCL2 / genetics Echocardiography Hyperaldosteronism / chemically induced, complications*, metabolism* Male Myocarditis / etiology, metabolism, ultrasonography Osteopontin Oxidative Stress* RNA, Messenger / analysis Rats Rats, Sprague-Dawley Sialoglycoproteins / genetics Sodium Chloride, Dietary / pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Ccl2 protein, rat; 0/Chemokine CCL2; 0/RNA, Messenger; 0/Sialoglycoproteins; 0/Sodium Chloride, Dietary; 0/Spp1 protein, rat; 106441-73-0/Osteopontin; 52-39-1/Aldosterone; 616-91-1/Acetylcysteine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Augmentation of pulse wave velocity precedes vascular structural changes of the aorta in rats treate...
Next Document: Role of chymase-dependent angiotensin II formation in regulating blood pressure in spontaneously hyp...