| Excess aldosterone is associated with alterations of myocardial texture in primary aldosteronism. | |
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MedLine Citation:
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PMID: 12105133 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hyperaldosteronism has been causally linked to myocardial interstitial fibrosis experimentally, but it remains unclear if this link also applies to humans. Thus, we investigated the effects of excess aldosterone due to primary aldosteronism (PA) on collagen deposition in the heart. We used echocardiography to estimate left ventricular (LV) wall thickness and dimensions and for videodensitometric analysis of myocardial texture in 17 consecutive patients with PA and 10 patients with primary (essential) hypertension who were matched for demographics, casual blood pressure, and known duration of hypertension. The groups differed in serum K+, ECG PQ interval duration, plasma renin activity, and aldosterone levels (all P< or =0.002) but not for casual blood pressure values, demographics, and duration of hypertension. Compared with hypertensive patients, PA patients showed a higher LV mass index (53.7+/-1.8 versus 45.5+/-2.0 g/m(2.7); P=0.008) and lower values of the cyclic variation index of the myocardial mean gray level of septum (CVI(s); -12.02+/-5.84% versus 6.06+/-3.08%; P=0.012) and posterior wall (-11.13+/-6.42% versus 8.63+/-9.62%; P=0.012). A regression analysis showed that CVI(s) was predicted by the PQ duration, supine plasma renin activity, plasma aldosterone, and age, which collectively accounted for approximately 36% of CVI(s) variance. PA is associated with alterations of myocardial textures that suggest increased collagen deposition and that can explain both the dependence of LV diastolic filling from presystole and the prolongation of the PQ interval. |
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Authors:
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Gian Paolo Rossi; Vitantonio Di Bello; Chiara Ganzaroli; Alfredo Sacchetto; Maurizio Cesari; Alessio Bertini; Davide Giorgi; Roldano Scognamiglio; Mario Mariani; Achille C Pessina |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hypertension Volume: 40 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-07-09 Completed Date: 2002-07-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
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Languages: eng Pagination: 23-7 Citation Subset: IM |
Affiliation:
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Cardiac and Thoracic Department, University of Pisa, Italy. gianpaolo.rossi@unipd.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aldosterone / blood* Echocardiography, Doppler Female Heart / physiopathology* Heart Ventricles / pathology, physiopathology Humans Hyperaldosteronism / blood*, pathology, physiopathology Hypertension / blood, pathology, physiopathology Male Middle Aged Myocardium / pathology* |
| Chemical | |
Reg. No./Substance:
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52-39-1/Aldosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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