Document Detail


Excess adiposity, inflammation, and iron-deficiency in female adolescents.
MedLine Citation:
PMID:  19167957     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Iron deficiency is more prevalent in overweight children and adolescents but the mechanisms that underlie this condition remain unclear. The purpose of this cross-sectional study was to assess the relationship between iron status and excess adiposity, inflammation, menarche, diet, physical activity, and poverty status in female adolescents included in the National Health and Nutrition Examination Survey 2003-2004 dataset. Descriptive and simple comparative statistics (t test, chi(2)) were used to assess differences between normal-weight (5th < or = body mass index [BMI] percentile <85th) and heavier-weight girls (< or = 85th percentile for BMI) for demographic, biochemical, dietary, and physical activity variables. In addition, logistic regression analyses predicting iron deficiency and linear regression predicting serum iron levels were performed. Heavier-weight girls had an increased prevalence of iron deficiency compared to those with normal weight. Dietary iron, age of and time since first menarche, poverty status, and physical activity were similar between the two groups and were not independent predictors of iron deficiency or log serum iron levels. Logistic modeling predicting iron deficiency revealed having a BMI > or = 85th percentile and for each 1 mg/dL increase in C-reactive protein the odds ratio for iron deficiency more than doubled. The best-fit linear model to predict serum iron levels included both serum transferrin receptor and C-reactive protein following log-transformation for normalization of these variables. Findings indicate that heavier-weight female adolescents are at greater risk for iron deficiency and that inflammation stemming from excess adipose tissue contributes to this phenomenon. Food and nutrition professionals should consider elevated BMI as an additional risk factor for iron deficiency in female adolescents.
Authors:
Lisa M Tussing-Humphreys; Huifang Liang; Elizabeta Nemeth; Sally Freels; Carol A Braunschweig
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Dietetic Association     Volume:  109     ISSN:  0002-8223     ISO Abbreviation:  J Am Diet Assoc     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-26     Completed Date:  2009-03-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503061     Medline TA:  J Am Diet Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  297-302     Citation Subset:  AIM; IM    
Affiliation:
Department of Kinesiology and Nutrition, Applied Health Sciences, University of Illinois, Chicago, IL, USA. ltussing@uic.edu
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MeSH Terms
Descriptor/Qualifier:
Adiposity* / physiology
Adolescent
Anemia, Iron-Deficiency / blood,  epidemiology*
Body Mass Index*
C-Reactive Protein / analysis
Comorbidity
Cross-Sectional Studies
Female
Humans
Inflammation / blood,  epidemiology*
Iron, Dietary / administration & dosage
Logistic Models
Menarche / physiology
Nutrition Surveys
Obesity / blood,  epidemiology
Odds Ratio
Overweight / blood,  epidemiology*
Poverty
Predictive Value of Tests
Prevalence
Receptors, Transferrin / metabolism
Risk Factors
United States / epidemiology
Chemical
Reg. No./Substance:
0/Iron, Dietary; 0/Receptors, Transferrin; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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